Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Anti-PD1 antibody led to a significant decrease in the number of OS lung metastases, enhanced tumor apoptosis, decreased tumor cell proliferation, and p-STAT-3/p-Erk1/2 signaling blockade in OS lung tumors. 29733528 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Efficacy of the FLLL32 pharmacological inhibitor in delaying OS growth suggests that targeting JAK2/STAT3 may be a potential therapeutic strategy for patients with OS. 25760445 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE These results suggest that E2F1/DDR1/STAT3 pathway is critical for malignancy of osteosarcoma, which may provide a novel prognostic indicator or approach for osteosarcoma therapy. 29039472 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE STAT3 appears to be an important mediator of chemoresistance in osteosarcoma. 30430945 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE Importantly, TBL1XR1 enhanced the tumorigenicity of osteosarcoma cells via activating STAT3 signaling and TBL1XR1 expression correlated significantly with STAT3 phosphorylation in osteosarcoma. 30529193 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE In our previous work, we found that several canine and human osteosarcoma (OSA) cell lines, but not normal osteoblasts, exhibit constitutive phosphorylation of STAT3. 21443800 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE In addition, knockdown of LIF notably suppressed the proliferation and invasion of osteosarcoma via blocking the STAT3 signal pathway; in contrast, treatment with the recombinant LIF protein significantly promoted the growth and invasion of osteosarcoma through enhancing the phosphorylation of STAT3, which can be partially neutralized by the STAT3 inhibitor, HO-3867. 26271643 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE STAT3 phosphorylation has been demonstrated in a subset of human osteosarcoma (OSA) tissues and cell lines. 19284568 2009
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE We found that SC repressed cell viability and migration and induced apoptosis in vitro, while combined SC and erlotinib treatment enhanced osteosarcoma growth suppression by preventing feedback activation of STAT3. 31422383 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE This study investigated whether miR-29 regulates the STAT3 expression and affects the proliferation and apoptosis of osteosarcoma cells. 31539114 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE miR-340-5p gene expression in OS tissues and U2OS cells was significantly lower than that in paracancerous tissues and hFOB1.19 cells. miR-340-5p directly interacted with the 3'-untranslated region (3'-UTR) of STAT3 gene and negatively regulated its expression. 30779064 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Role of the HDAC6/STAT3 pathway in regulating PD-L1 expression in osteosarcoma cell lines. 30430228 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE These results collectively reveal that STAT3 regulates the transcription of STK35 in osteosarcoma. 29414823 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE <b>Conclusion:</b> These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway. 31371981 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Finally, blockade of STAT3 by WP1066 (a STAT3 inhibitor) further enhanced the effect of irisin on the EMT and Snail expression in osteosarcoma cells. 29048621 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE We found that SOX18, IL-6 and p-STAT3 were elevated in osteosarcoma compared with bone cyst tissues. 29184419 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Stat3 upregulates leucine-rich repeat-containing g protein-coupled receptor 4 expression in osteosarcoma cells. 24455684 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE We found that CA concentration-dependently inhibited the activation of the STAT3/Snail pathway in osteosarcoma cells. 30582213 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Furthermore, we showed that Stat3 activity was crucial for IL-17A/IL-17RA interaction to promote OS metastasis. 23192273 2013