Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells. 31000382 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE SIX1 promoted the progression of osteosarcoma via regulating PTEN/PI3K/AKT signaling cascade, which might provide a new potent therapeutic target for osteosarcoma. 29807230 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway. 28053596 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We also found that the activations of phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) were considerably reduced after osteosarcoma cells were treated with Lv-shVEGF. 27352347 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma. 30014744 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management. 28565856 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Based on the above results, we conclude that PTEN/PI3K/Akt signaling is involved in the inhibitory effect on human OS 143B cell proliferation by EVO. 26135006 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway. 31340526 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE X-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells. 30249882 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Aplasia Ras homologue member Ⅰ overexpression inhibits tumor growth and induces apoptosis through inhibition of PI3K/Akt survival pathways in human osteosarcoma MG-63 cells in culture. 26165148 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE A005 inhibited tumor growth and prevented osteosarcoma-associated osteolysis via modulation of the PI3K/AKT/mTOR pathway. 29635391 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE ISL could retard proliferation and promote apoptosis of U2OS cells possibly by suppressing the PI3K/Akt signalling pathway, indicating that it might be a potential therapeutic agent for osteosarcoma treatment. 29936511 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Western blot analyses revealed that circ-0001785 regulated the PI3K/Akt signaling and Bcl-2 family pathway in osteosarcoma. 31116090 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE In addition, we further found that those effects on osteosarcoma by NRSN2 are associated with the dysregulated PI3K/AKT/mTOR signaling and Wnt/β-catenin signaling. 28401012 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Analysis of the signalling relationships of these genes, as well as other expression markers of osteosarcoma, indicated that gene networks linked to RB1, TP53, PI3K, PTEN/Akt, myc and RECQL4 are associated with osteosarcoma. 24835790 2014
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE In conclusion, the results of the present study indicated that CLDN12 promoted cell proliferation and migration through the PI3K/Akt signaling pathway in osteosarcoma cells, suggesting that CLDN12 may be a potential agent in the treatment of patients with osteosarcoma. 31807064 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway. 28932123 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Lupeol suppresses migration and invasion <i>via</i> p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells. 31010399 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE K-Ras<sup>G12V/Y40C</sup>-PI3K/AKT pathway regulates H1.4<sup>S35ph</sup> through PKA to promote the occurrence and development of osteosarcoma cancer. 31126199 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE In summary, our data demonstrated that downregulation of HOXB7 inhibited proliferation, invasion, and tumorigenesis, partly through suppressing the PI3K/Akt signaling pathway in osteosarcoma cells. 27983923 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Our data suggest that upregulation of pro-inflammatory cytokine signal in the periaqueductal gray of cancer rats amplifies PI3K-mTOR signal in this brain region and alters the descending pathways in regulating pain transmission, and this thereby contributes to the development of bone cancer-induced pain. 30717619 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Moreover, FAK, PI3K, Akt and NF-κB activation were also shown to be involved in CTGF-mediated osteosarcoma metastasis. 29909077 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma. 30092789 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Honokiol induces autophagy and apoptosis of osteosarcoma through PI3K/Akt/mTOR signaling pathway. 29207060 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Here, we review these cancer signaling pathways, including Notch, Wnt, Hedgehog, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT, and JAK/STAT, and their specific role in osteosarcoma. 28061797 2017