Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE Our results indicate that TGF-α/EGFR interaction elicits PI3K and Akt activation, which in turn activates NF-κB, resulting in the expression of ICAM-1 and contributing the migration of human osteosarcoma cells. 24685520 2014
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells. 31000382 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE PP2A was a direct target of miR-21, which participated in the effects of ASBEL and miR-21 on the activation of phosphatidylinositol 3-kinase/protein kinase 3/glycogen synthase kinase-3β (PI3K/AKT/GSK3β) and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathways as well as the enhancement of osteosarcoma cell proliferation, migration, and invasion. 29323740 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Rationale combinations of specific PI3K and mTOR inhibitors could recapitulate the effect on osteosarcoma cell cultures. 25862761 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE SIX1 promoted the progression of osteosarcoma via regulating PTEN/PI3K/AKT signaling cascade, which might provide a new potent therapeutic target for osteosarcoma. 29807230 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Taken together, our results suggest that miR-497 modulates the sensitivity to cisplatin at least in part through PI3K/Akt pathway in osteosarcoma cells. 26202364 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE Taken together, XBP1 is up-regulated and has a pro-tumor effect in OS with activation of PI3K/mTOR signaling. 26633383 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE The activation of PI3K/Akt and the overexpression of fatty acid synthase (FASN) are frequently observed in human osteosarcoma (OS). 24366211 2014
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE The overexpression of IRX2 promoted the activation of PI3K/Akt and increased the proliferation and invasiveness of the OS cell lines as shown by CCK8 and invasion assays. 26062523 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression disease BEFREE The relative protein expression level of p-PI3K, p-Akt, P53 and Bcl-2 in osteosarcoma cells after transfection with lncRNA- NC or lncRNA-LINC00628 were detected by Western blot. 30280767 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways. 30914203 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Then, we showed that TSSC3 overexpression enhanced autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway in osteosarcoma. 30092789 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Therefore, the current study reveals that aclidinium bromide might inhibit osteosarcoma cell growth by regulating the PI3K/AKT signaling pathway, which suggests aclidinium bromide is a potential chemotherapeutic agent for osteosarcoma. 30657552 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE These findings suggest that galangin suppresses osteosarcoma cells by inhibiting their proliferation and invasion and accelerating their apoptosis, and the mechanism may be associated with the inhibition of PI3K and its downstream signaling pathway. 27840963 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE These results suggest that the FASN/HER2/PI3K/Akt signaling pathway may be a potential therapeutic target for OS management. 28565856 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE This study investigated the role of miR-155 in regulating osteosarcoma cell autophagy, chemosensitivity to Adriamycin (ADM), and PTEN-PI3K/AKT/mTOR signaling pathway. 29412697 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Valosin-containing protein (VCP) promotes the development of metastasis in osteosarcoma (OS) via the PI3K/Akt signaling pathway. 31516594 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We also found that the PI3K/Akt signaling pathway was involved in the tumor-promoting effect of USP22 on OS progression. 27983930 2017
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We also found that the activations of phosphoinositide 3-kinase (PI3K) and protein kinase B (AKT) were considerably reduced after osteosarcoma cells were treated with Lv-shVEGF. 27352347 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We determined that AREG increases the expression of intercellular adhesion molecule-1 (ICAM-1) through PI3K/Akt signaling pathway via its interaction with the epidermal growth factor receptor, thus resulting in the enhanced cell migration of osteosarcoma. 26503469 2015
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We discovered that TIIA inhibited osteosarcoma cell survival through class I PI3K and Akt signaling pathways. 30258193 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We found that hBMSC-MVs promoted U2OS cell proliferation and migration under hypoxia in vitro, and that was partially associated with the PI3K/AKT and HIF-1α pathways. 30506278 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE We proposed that VRK1 and H2A<sup>T120ph</sup> could be the potential targets for osteosarcoma diagnosis and treatment.HighlightsH2A<sup>T120ph</sup> is specifically promoted by Ras-PI3K pathway activation.H2A<sup>T120ph</sup> joins in the oncogenic effects of Ras-PI3K pathway on osteosarcoma.H2A<sup>T120ph</sup> regulates the transcription of Ras-PI3K-targeted genes.VRK1 takes part in the regulatory function of Ras-PI3K pathway on H2A<sup>T120ph</sup>. 31810390 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Western blot analyses revealed that circ-0001785 regulated the PI3K/Akt signaling and Bcl-2 family pathway in osteosarcoma. 31116090 2019
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 Biomarker disease BEFREE Western blot analysis was performed to detect the expression levels of phosphatidylinositol 3‑kinase (PI3K), phospho (p)‑PI3K, RAC‑alpha serine/threonine‑protein kinase (AKT), p‑AKT and NF‑κB inhibitor α (IκBα) in osteosarcoma cells transfected with H19 siRNA. 29568924 2018