Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Interleukin-1β/nuclear factor-κB signaling promotes osteosarcoma cell growth through the microRNA-181b/phosphatase and tensin homolog axis. 30977354 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Our results show that microglia in the spinal cord presented increased M1 polarization and decreased M2 polarization, while overproduction of IL-1β and inhibited expression of IL-10 was detected during bone cancer pain development. 29882480 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE IL-1β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1. 28926924 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Furthermore, administration of berberine is capable of reducing the expression of caspase-1 and IL-1β in osteosarcoma cells and inhibiting the growth of tumor cells. 28000894 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Hence, the regulation of IL-1β/NF-κB/miR-376c/TGFA signaling in OS might present a promising strategy for the treatment of OS. 29441940 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE The aim of this study was to investigate the association between IL-1B gene polymorphisms and osteosarcoma risk in Chinese Han patients. 24878968 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Tumor necrosis factor-α, interleukin-1β and LPS enhanced osteosarcoma U2OS MMP-9 secretion but had no effect on MMP-2 secretion. 24190483 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE We examined the effect of IL-1 on FGF-2 mRNA and protein expression in human osteosarcoma MG-63 osteoblasts, normal human osteoblasts (NHOB), and osteoblasts from osteoarthritic patients (F2 and F13). 11485304 2001
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE In this study we analyzed the effects of IL-1 on the intracellular distribution of PI3-kinase in wild-type Saos-2 human osteosarcoma cells, and in cell clones overexpressing type I IL-1 receptor (IL-1RI). 9973598 1999
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE This study examines the effects of IL-1 on PGHS-2 mRNA expression in human osteosarcoma MG-63 cells, the human osteoblast-like initial transfectant (HOBIT) cell line, and primary human osteoblastic (HOB) cells. 9661070 1998
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Recombinant human IL-1 beta inhibits human osteosarcoma cell proliferation, stimulates integrin expression, and induces alkaline phosphatase activity, a marker of osteoinductive and osteoblastic phenotype. 2786815 1989
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE These data indicate that the beta 1 integrin family of cell surface receptors is a target for regulation by IL-1 beta, which also regulates cell proliferation and the expression of the osteoblastic phenotype in human osteosarcoma cells. 2521862 1989
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE A factor that promotes the growth of certain B cell hybridomas and of plasmacytomas is shown to be produced by normal human fibroblasts and by a line of human osteosarcoma cells (MG-63) after treatment with IL-1 or TNF. 3493322 1987