Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE Their increased metastatic potential and elevated IL-8 expression suggest a novel strategy for future therapeutic interventions to prevent osteosarcoma progression and metastasis. 31366916 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE The present study might lead not only to the clarification of a new molecular mechanism of invasion and metastasis of OS, but also to the development of a new therapeutic strategy of blocking IL-8 in OS. 29625612 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE By screening the expression of cytokines involved in the progression of OS, we found that activation of GPER can inhibit the expression of interleukin-6 (IL-6) and IL-8 in OS cells. 30385323 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE These results identify IL-6 and CXCL8 as primary mediators of OS lung tropism and suggest pleiotropic, redundant mechanisms by which they might effect metastasis. 30135299 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription. 30273544 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE CXCR1/Akt signaling activation induced by mesenchymal stem cell-derived IL-8 promotes osteosarcoma cell anoikis resistance and pulmonary metastasis. 29915309 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE We found that serum concentrations of CXCL8 and vascular endothelial growth factor were elevated in osteosarcoma patients in comparison with those in NCs. 28736978 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 AlteredExpression disease BEFREE An increased expression of IL6 and IL8 were found only in normal stromal cells, but not in OS cells, and this was confirmed in tumor-associated stromal cells isolated from OS tissue. 27888521 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 GeneticVariation disease BEFREE Our results showed that the IL-8 -251 A/T genotype was associated with increased risk for development and metastasis of osteosarcoma in Chinese Han population. 26615418 2016
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 GeneticVariation disease BEFREE These data indicated that IL-1Ra, IL-6, IL-8, and TNF-α were associated with increased risk of OS, in which IL-8 and TNF-α may be further correlated with the progression of this disease. 23999825 2014
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE We have previously reported that titanium particles stimulate the selective induction of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human osteoblast-like osteosarcoma cells. 16392133 2006
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker disease BEFREE Human granulocyte chemotactic protein 2 (GCP-2) has originally been isolated from cytokine-stimulated osteosarcoma cells as a chemokine coproduced in minute amounts together with interleukin 8. 9054580 1997