| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Our preclinical work indicates that anlotinib acts as a novel inhibitor of VEGFR2 and MET that blocks tumorigenesis in osteosarcoma, which could be translated into future clinical trials. | 30719715 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Expression levels of miR-206, PAX3, and MET mRNA were explored in paired OS and adjacent tissue specimens. | 30666838 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Our data assessed specific miRNA profiling deregulation in OS clinical samples and suggest that the expression of miR-1 and miR-133b may control cell proliferation and cell cycle through MET protein expression modulation. | 23229283 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | These data show that MET initiates the transformation of a cell population that has features of osteo-progenitors and suggest that MET regulates self-renewal and lineage differentiation of osteosarcoma cells. | 22367914 | 2012 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The Met receptor tyrosine kinase (RTK) is aberrantly expressed in human osteosarcoma and is an attractive molecular target for cancer therapy. | 19402129 | 2009 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | MET activating mutations are rarely found in other human tumors, whereas at higher frequencies, MET is amplified and/or overexpressed in sporadic tumors of specific histotypes, including osteosarcoma. | 16651428 | 2006 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The highest levels of Met/HGF receptor were found in osteosarcoma, a highly aggressive tumor that typically permeates the host bone and rapidly expands to the soft tissues. | 8863670 | 1996 | ||||
|
0.080 | Biomarker | disease | BEFREE | The TPR-MET oncogenic rearrangement was originally observed in an in vitro transformed human osteosarcoma cell line. | 2052572 | 1991 |