Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Immunofluorescence was used to observe changes in transforming growth factor β1 (TGF-β1) protein expression levels in the osteosarcoma cells following drug administration. 31579425 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE The study demonstrated that circ_0051079 could act as an oncogene via regulating miR-26a-5p/TGF-β1 and a potential biomarker for osteosarcoma diagnose. 31798828 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Our findings implied that the novel identified NEAT1/miR-339-5p/TGF-β1 axis might be a new molecular pathway or therapeutic target for OS diagnosis and treatment. 30203547 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE MicroRNA-1269a promotes the occurrence and progression of osteosarcoma by inhibit-ing TGF-β1 expression. 30779063 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Our results suggest that PDCD5 may attenuate EMT by inhibiting TGF-β1/Smad signaling pathway to inhibit OS metastasis and may be a potential adjuvant genetic therapy for OS. 30899411 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE The osteosarcoma cell lines expressed all three TGF-β isoforms, with TGF-β1 being the most abundant isoform. 29577601 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Serum miRNA-21 may be used to effectively diagnose osteosarcoma and predict the prognosis of the disease. miRNA-21 knockdown inhibited the proliferation of osteosarcoma and promoted the expression of PTEN and TGF-β1 proteins in the osteosarcoma cells. 30250537 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE In addition, ICAM1, PDGFB, PDGFRB and TGFB1, which were involved in cell migration and regulation of cell migration may affect the metastasis of OS. 29328361 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE In conclusion, our study demonstrated that oridonin inhibited EMT and TGF-β1-induced EMT by inhibiting TGF-β1/Smad2/3 signaling pathway in osteosarcoma. 30243739 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Chimaphilin inhibits human osteosarcoma cell invasion and metastasis through suppressing the TGF-β1-induced epithelial-to-mesenchymal transition markers via PI-3K/Akt, ERK1/2, and Smad signaling pathways. 28177668 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 GeneticVariation disease BEFREE Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms. 29228633 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE In addition, targeting TGF-β1 to induce osteogenic differentiation might represent a novel therapeutic strategy to treat osteosarcoma with minimal side effects. 28340520 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Further results suggested that miR-210 promoted the expression of TGF-β1 and its downstream effectors Snail1 and Slug which were highly elevated in the process of OS dedifferentiation. 28032372 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Propofol suppresses invasion and induces apoptosis of osteosarcoma cell in vitro via downregulation of TGF-β1 expression. 27097968 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Furthermore, the co-culturing with MSC stimulated the migratory capacity of OS via TGFβ1 and IL-6 secretion, and the neutralizing antibody anti-IL-6 impaired this effect. 27851822 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Targeting miR-29 exhibits significant in vivo and in vitro anti-tumor activities in OS through a novel mechanism resulting in inhibition of TGF-β1 expression and inducing PUMA expression. 27649654 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE We found that miR-202 is overexpressed in osteosarcoma tissues when compared with normal human osteoblasts and TGF-β1 can induce the expression of miR-202. 26276504 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 GeneticVariation disease BEFREE TaqMAN PCR technique was used to detect the TGF-β1 gene polymorphism of 124 patients with osteosarcoma from last follow-up and 136 healthy controls. 25663491 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 PosttranslationalModification disease BEFREE The aim of this study was to evaluate the roles of versican in TGF-β1-induced osteosarcoma cell migration and invasion. 25562163 2014
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE TGFbeta was found to induce marked elongation of TSP-1 mRNA longevity in osteosarcoma cells when mRNA degradation was assayed in the presence of alpha-amanitin. 11955611 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Similarly, mRNA levels of TGF beta 1 detected by in situ hybridization were significantly higher (p = 0.04, Fisher's exact test) in high-grade osteosarcoma variants, while no differences were found for TGF beta 2 and -3 mRNA (p = 1.0; p = 0.2, respectively; Fisher's exact test). 9771482 1998
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression disease BEFREE Therefore, we conclude that glucocorticoid receptor function is mediated by the activation of latent-TGF beta 1 in MG-63 osteosarcoma cells. 7768643 1995
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. 7817811 1994