Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | phenotype | BEFREE | OPRM1 and COMT polymorphisms were associated with AEs in CNCP patients that differed according to gender. | 31745220 | 2020 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Based on this information we analyzed the influence from the COMT Val158Met polymorphism on the efficacy of morphine in a cohort of patients suffering from cancer pain. | 15927391 | 2005 | ||||
|
0.080 | PosttranslationalModification | phenotype | BEFREE | We assessed joint effects of the OPRM1 and COMT genes in predicting morphine dose for cancer pain relief. | 17156920 | 2007 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Present research suggests that the A allele in COMT polymorphism could be a marker of opioid sensitivity in paediatric cancer patients (STOP Pain), as well as in adults (Systematic Review), indicating that the polymorphism impact could be not age-dependent in the cancer pain context. | 30704436 | 2019 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Genetic variation in the COMT gene has been implicated in variable response to various experimental painful stimuli, variable susceptibility to develop common pain conditions, as well as the variable need for opioids in the treatment of cancer pain. | 19374521 | 2009 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | Low COMT activity increases opioid receptors and enhances opioid analgesia and adverse effects in some cancer pains. | 22722321 | 2012 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | A low COMT activity also increases availability of opioid receptors and may enhance opioid analgesia and adverse effects at least in cancer pains. | 21095465 | 2010 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment. | 29259946 | 2017 |