Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 GeneticVariation phenotype BEFREE OPRM1 and COMT polymorphisms were associated with AEs in CNCP patients that differed according to gender. 31745220 2020
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 GeneticVariation phenotype BEFREE Present research suggests that the A allele in COMT polymorphism could be a marker of opioid sensitivity in paediatric cancer patients (STOP Pain), as well as in adults (Systematic Review), indicating that the polymorphism impact could be not age-dependent in the cancer pain context. 30704436 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 Biomarker phenotype BEFREE Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment. 29259946 2017
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 AlteredExpression phenotype BEFREE Low COMT activity increases opioid receptors and enhances opioid analgesia and adverse effects in some cancer pains. 22722321 2012
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 AlteredExpression phenotype BEFREE A low COMT activity also increases availability of opioid receptors and may enhance opioid analgesia and adverse effects at least in cancer pains. 21095465 2010
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 GeneticVariation phenotype BEFREE Genetic variation in the COMT gene has been implicated in variable response to various experimental painful stimuli, variable susceptibility to develop common pain conditions, as well as the variable need for opioids in the treatment of cancer pain. 19374521 2009
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 PosttranslationalModification phenotype BEFREE We assessed joint effects of the OPRM1 and COMT genes in predicting morphine dose for cancer pain relief. 17156920 2007
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.080 GeneticVariation phenotype BEFREE Based on this information we analyzed the influence from the COMT Val158Met polymorphism on the efficacy of morphine in a cohort of patients suffering from cancer pain. 15927391 2005