RNAseq was performed on a representative clone to comprehensively examine the transcriptional cellular signature in response to xCT knockdown, identifying multiple differentially regulated factors relevant to cancer pain including nerve growth factor, interleukin-1, and colony-stimulating factor-1.
This neurotrophic role of NGF in cancer is likely to be relevant to a large variety of human malignancies, as well as other neurotrophins, and may have ramifications in cancer pain.
Cumulatively, these data suggest that the activation of TrkA by nerve growth factor may have functional implications on system x<sub>C</sub><sup>-</sup>-mediated cancer pain.