Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Disruption of the Raf/MEK/ERK (MAPK) kinase pathway, either by RAS or BRAF mutation, was detected in approximately 62% of all CC and is therefore one of the most frequent defects in cholangiocellular carcinogenesis. 12692057 2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE A tumor suppressor gene, p16, was found to harbor promoter methylation associated with the loss of protein expression in cancer cells, suggesting that p16 inactivation due to promoter methylation may be important for gastric tumorigenesis. 20683001 2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE Two members of the Ras/Raf signaling pathway, KRAS and B-raf, are suspected to be involved in the stepwise progression of colorectal cancer (CRC) tumorigenesis. 24942334 2015
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE These findings provide what we believe is the first evidence for a role for Hunk in primary tumorigenesis and cell survival and identify this kinase as an essential effector of the HER2/neu oncogenic pathway. 21393859 2011
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Abolition of p21(Cip1/Waf1) and p16(Ink4a) functions prevented oncogenically activated Ras from inducing growth arrest and was sufficient for limited anchorage-independent growth but not tumorigenesis. 12665584 2003
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis. 22808230 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE Role of BRAF in thyroid oncogenesis. 21900390 2012
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE Our results, especially the in vivo data, provide fundamental support for developing metformin-mediated preventive strategies targeting ErbB2-associated carcinogenesis. 24322659 2014
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE This review presents the current evidence highlighting the role of HER3 in tumorigenesis and its role in mediating resistance to inhibitors of EGFR and HER2. 17667926 2007
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE A strong correlation was observed between the promoter methylation of RASSF1A gene but not p16 gene (both frequently inactivated by promoter methylation in lung cancer) and expression of DeltaDNMT3B4 in primary lung cancer, suggesting a role of DeltaDNMT3B in regulating promoter-specific methylation of common tumor suppressor genes in tumorigenesis. 18006804 2007
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 GeneticVariation phenotype BEFREE Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. 21559085 2011
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE The present study was undertaken to define whether c-myc, int2/FGF3 (11q13 region) and c-erbB2/neu genes are involved in prostate tumorigenesis. 7960236 1994
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Our findings stress the dual role of Nrf2 in carcinogenesis, while offering approaches to exploit Nrf2 as a potent therapeutic target in ovarian cancer. 25841766 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE B-Raf is dispensable for K-Ras-mediated oncogenesis in human cancer cells. 15026326 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE In addition, the alterations of the p16 gene might not play a major role in tumorigenesis of malignant gliomas in Malaysian patients. 15679305 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Our results in this limited series of central PNET show that p14/ARF is frequently involved in PNET carcinogenesis, with a higher frequency, but not statistically significant, for sPNET than for MB. 16623784 2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression phenotype BEFREE Furthermore, knockdown of Bmi-1 expression in CD133(+) cells led to inhibition of cell growth, colony formation, cell invasion in vitro, and tumorigenesis in vivo, through up-regulation of p16(INK4A) and p14(ARF). 26081615 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE From the data, it can be argued that p16/CDKN2 and p53 mutations are relatively late occurrences in human oral tumorigenesis and that genetic alterations of the ras genes may not play a significant role in squamous neoplasia. 8835820 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE We hypothesize that the presence of the fourth product, pALT(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance to tumorigenesis of this species. 25550505 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE The presence of BRAF V600E and mitogen-activated protein kinase activation in a largely benign tumor supports the necessity for secondary events (e.g., p16 loss) in BRAF-driven oncogenesis. 22727996 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE Moreover, LRP6 phosphorylation by ERK1/2 may provide a unique point of convergence between KRAS/MAPK and Wnt/β-catenin signalings during oncogenesis. 25500543 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE BRAF pseudogene function was studied by Western blots, soft agar assay, and tumorigenesis in nude mice. 19107232 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE Our results suggest that epigenetic alterations of p16 and RAR-β have an important role in ovarian carcinogenesis and that mechanism along with methylation plays a significant role in downregulation of RAR-β gene in ovarian cancer. 24913706 2014
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE Deregulated Her2/ErbB2 receptor tyrosine kinase drives tumorigenesis and tumor progression in a variety of human tissues. 17982484 2008
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. 16901776 2006