Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51352
Gene Symbol: WT1-AS
WT1-AS
0.020 AlteredExpression phenotype BEFREE In 4 of these tumors, reduced expression of WT1 and WIT1, genes located at 11p13 and implicated in Wilms tumorigenesis, was noted. 1283321 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Additional regulators of apoptosis, such as the p53 tumor suppressor gene, may be altered in human cancers as one step in tumorigenesis. 1286168 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE The data indicate an increased incidence of p53 abnormalities in the late stages of gastric carcinogenesis. 1302567 1993
Entrez Id: 51750
Gene Symbol: RTEL1
RTEL1
0.010 Biomarker phenotype BEFREE The results indicate that B-cell and T-cell sinonasal NHL are associated with EBV in Western as well as in Asian patients, and that EBV may have a role in oncogenesis in NHL of the upper aerodigestive tract. 1310241 1992
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation phenotype BEFREE Further studies to search for alterations of the WT1 gene in tumors and to identify regulatory factors in gene expression will increase understanding of the role of this gene in normal development and tumorigenesis. 1311774 1992
Entrez Id: 2191
Gene Symbol: FAP
FAP
0.040 GeneticVariation phenotype BEFREE A comparison of the incidence rate of colon cancer in the general population with that in patients with polyposis suggests that a mutation at the FAP gene locus is not one of the rate-limiting events in colon carcinogenesis. 1313509 1992
Entrez Id: 2191
Gene Symbol: FAP
FAP
0.040 Biomarker phenotype BEFREE Retinoblastoma (RB) and the familial adenomatous polyposis/colorectal cancer (FAP/CRC) complex provide well-characterised examples of multistage carcinogenesis and inheritance of a predisposition to cancer. 1314630 1992
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation phenotype BEFREE As a result, both the WT1 gene located in chromosome 11p13 and an unidentified gene(s) within chromosome 11p15 have been implicated in Wilms' tumorigenesis. 1317258 1992
Entrez Id: 324
Gene Symbol: APC
APC
0.100 GeneticVariation phenotype BEFREE These results suggest that the mutation of the APC gene also plays an important role during the carcinogenesis of at least some gastric cancers. 1317264 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Moreover, the presence of 15 cases of glioblastoma with loss of chromosome 10 but without EGFR gene amplification may further imply that the loss of a tumor suppressor gene (or genes) on chromosome 10 precedes EGFR gene amplification in glioblastoma tumorigenesis. 1320666 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE These results indicate that inactivation of the p53 gene through mutations and the allelic deletion may play an important role in gastric tumorigenesis. 1322785 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Participation of p53 in this pathway suggests a mechanism for the contribution of abnormalities in p53 to tumorigenesis and genetic instability and provides a useful model for studies of the molecular mechanisms of p53 involvement in controlling the cell cycle. 1323840 1992
Entrez Id: 324
Gene Symbol: APC
APC
0.100 GeneticVariation phenotype BEFREE These data suggest that more than one gene on chromosome 5q21 may contribute to colorectal carcinogenesis and that mutations at the APC gene can cause both adenomatous polyposis coli and Gardner's syndrome. 1324739 1992
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 AlteredExpression phenotype BEFREE We examined the effects of TGF-beta on growth and virus early-gene expression in cell lines immortalized by two HPV types associated with cervical carcinogenesis as well as the expression of TGF-beta 1 mRNA transcripts in normal and HPV-positive cells in vivo and in vitro. 1326988 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE A previous report using cervical carcinoma cell lines suggests that the inactivation of two tumor suppressor gene products, p53 and pRB, either by complex formation with the E6 and E7 proteins of oncogenic human papillomaviruses (HPVs) or by mutation, may be an important step in cervical carcinogenesis (M. Scheffner et al., Proc.Natl.Acad.Sci.USA, 88: 5523-5527, 1991). 1327506 1992
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE Mutations in c-K-ras 2 gene codon 12 during colorectal tumorigenesis in familial adenomatous polyposis. 1333425 1993
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The loss of sequences on chromosome 10 and the deletions of 9p (that is loss of tumor suppressor genes on these locations), and epidermal growth factor receptor gene amplification, have been proposed as sequential abnormalities participating in glioblastoma tumorigenesis. 1336685 1993
Entrez Id: 3688
Gene Symbol: ITGB1
ITGB1
0.030 Biomarker phenotype BEFREE These facts indicate that a double positive T cell (CD29+, CD45RA+) was possibly the target cell for HTLV-I infection and that HTLV-I was not directly related to the oncogenesis of the monocyte lineage in the present case, even if it did infect the monocytes. 1337297 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE These findings are consistent with a recessive mechanism of action of p53 in WHO grade II and III astrocytoma tumorigenesis. 1349850 1992
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression phenotype BEFREE Amplification and overexpression of the c-erbB-2/neu gene has been shown in certain human tumors and is postulated to be important in human carcinogenesis. 1350198 1992
Entrez Id: 4758
Gene Symbol: NEU1
NEU1
0.050 Biomarker phenotype BEFREE Amplification and overexpression of the c-erbB-2/neu gene has been shown in certain human tumors and is postulated to be important in human carcinogenesis. 1350198 1992
Entrez Id: 9148
Gene Symbol: NEURL1
NEURL1
0.050 Biomarker phenotype BEFREE Amplification and overexpression of the c-erbB-2/neu gene has been shown in certain human tumors and is postulated to be important in human carcinogenesis. 1350198 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker phenotype BEFREE Two recent studies have examined the role of p53 in immortalization and tumorigenesis. 1365909 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE These observations further support the notion that germline p53 mutation plays a key role in the tumorigenesis of individuals with Li-Fraumeni syndrome. 1373881 1992
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.100 AlteredExpression phenotype BEFREE Critical in determining the role of IGF-II in tumorigenesis is the necessity to delineate factors affecting the transcription of IGF-II in normal and tumor tissues. 1375906 1992