Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression phenotype BEFREE Furthermore, knockdown of Bmi-1 expression in CD133(+) cells led to inhibition of cell growth, colony formation, cell invasion in vitro, and tumorigenesis in vivo, through up-regulation of p16(INK4A) and p14(ARF). 26081615 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 AlteredExpression phenotype BEFREE Taken together, these data suggest a role for redox-dependent activation of wild-type KRAS through C118 in oncogenic HRAS-driven tumorigenesis. 25902334 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE Here, we used a mouse model of KRAS-driven pancreatic carcinogenesis to define distinct subtypes of PDAC metastasis: epithelial, mesenchymal and quasi-mesenchymal. 26158412 2016
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis. 25997501 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE QPCR demonstrated in patients ≤45 years a higher expression of genes that are associated with carcinogenesis (CTNNB1, STK11, CDKN2A, HGF, MET) as well as tumor suppressors that constitute an enhanced radio-sensitivity (ATM, BRCA1E2F1, FHIT). 25633809 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. 26657862 2016
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE As ERBB signaling is also important for neural survival, HER2+ breast tumors may highjack DCD's neural survival-promoting functions to promote tumorigenesis. 25879571 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE These findings enhance our understanding of factors cooperating with BRAF inhibition that accelerate keratinocyte oncogenesis as well as broaden the knowledge base of multifactorial mediators of cancer in general. 25724524 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE KRAS mutation and alterations in CDKN2A are early events in pancreatic tumorigenesis. 26830752 2016
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 AlteredExpression phenotype BEFREE Human epidermal growth factor receptor 2 (HER2) is a key driver of tumorigenesis, and over-expression as a result of HER2 gene amplification has been observed in a number of solid tumors. 26626802 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis. 26385919 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE These data in conjunction with the work of others that have specified the role of PAK1 in transduction of KRAS signal bring forward the importance of KRAS/PAK1/Crk axis as a prominent pathway in the oncogenesis of KRAS mutant lung cancer. 25956913 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE An integral role for miRNAs in cancer pathogenesis is well established; however, the role of miRNAs in KRAS-mediated tumorigenesis is poorly characterized. 26747707 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Nrf2 and TGF-β1 both affect tumorigenesis in a dual fashion, either by preventing carcinogen induced carcinogenesis and suppressing tumor growth, respectively, or by conferring cytoprotection and invasiveness to tumor cells during malignant transformation. 26226105 2016
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Indicaxanthin exhibited anti-proliferative activity in all cell lines but HT29, induced demethylation in the promoters of some methylation-silenced onco-suppressor genes involved in colorectal carcinogenesis (p16INK4a, GATA4, and ESR1), and left unchanged others which were basally hypermethylated (SFRP1 and HPP1). 26439130 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE KRAS mutation-positive bronchial surface epithelium (BSE)-type lung adenocarcinoma with strong expression of TTF-1: a case providing a further insight as for the role of TTF-1 in the oncogenesis. 26823891 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis. 26567140 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Here, we studied the expression and function of the exportin cellular apoptosis susceptibility (CAS) in thyroid carcinogenesis and its link to the BRAF(V600E) mutation. 26892809 2016
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE Notably, although ErbB2 does not bind any ErbB ligands, ErbB2 may activate tumorigenesis via a heterodimer, rather than a homodimer. 26935861 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE With respect to carcinogenesis mechanisms, RCC is associated with known gene types, such as MMR, KRAS, BRAF, and miRNA-31, while LCC is associated with CIN, p53, NRAS, miRNA-146a, miRNA-147b, and miRNA-1288. 26074686 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Because the cancer initiating mutations in these hereditary syndromes are well defined, they offer a unique opportunity to explore the roles of NRF2 activation in the early stages of carcinogenesis. 26551707 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Functional Role of NRF2 in Cervical Carcinogenesis. 26247201 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Promoter hypermethylation and the BRAF(V) (600E) mutation are both involved in thyroid tumorigenesis. 25988212 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE The data suggest that coexpression of BRAF(V600E) and KRAS(G12D) in early tumorigenesis leads to negative selection due to oncogene-induced senescence. 26028035 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE The data suggest that coexpression of BRAF(V600E) and KRAS(G12D) in early tumorigenesis leads to negative selection due to oncogene-induced senescence. 26028035 2016