| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | phenotype | BEFREE | The 4-nitroquinoline 1-oxide (4-NQO) model for carcinogenesis has been used to investigate cancer stem cells (CSC), but no study has addressed the role of the p75 neurotrophin receptor (p75<sup>NTR</sup>) in 4-NQO-induced oral dysplasia and oral squamous cell carcinoma (OSCC). | 30268558 | 2018 | ||||
|
0.370 | AlteredExpression | phenotype | BEFREE | <i>N</i>-Glycan deletion on β4-integrin impaired β4-dependent cancer cell migration, invasion, and growth <i>in vitro</i> and diminished tumorigenesis and proliferation <i>in vivo</i> The reduced abilities of β4-integrin were accompanied with decreased phosphoinositol-3 kinase (PI3K)/Akt signals and were restored by the overexpression of the constitutively active p110 PI3K subunit. | 29549127 | 2018 | ||||
|
0.370 | Biomarker | phenotype | CTD_human | Thus, our complementary approaches identify CUX1 as a pan-driver of tumorigenesis and uncover a potential strategy for treating CUX1-mutant tumors. | 24316979 | 2014 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Thus, our complementary approaches identify CUX1 as a pan-driver of tumorigenesis and uncover a potential strategy for treating CUX1-mutant tumors. | 24316979 | 2014 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Several transcriptional targets and cellular functions of CUX1 affect tumorigenesis; however, we have yet to develop a mechanistic framework to reconcile the opposite roles of CUX1 in cancer protection and progression. | 25190083 | 2014 | ||||
|
0.370 | GeneticVariation | phenotype | BEFREE | Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer. | 23896864 | 2014 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Overexpression of constitutively active p110 phosphoinositol-3-kinase subunit was sufficient to restore invasion and tumorigenesis in transformed cells lacking laminin-332/collagen VII interaction in a manner independent of cellular adhesion. | 17483338 | 2007 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Taken together, these results suggest that aberrant expression of the CDP/Cux p75 isoform in mammary epithelial cells may be associated with the process of tumorigenesis in breast cancer. | 12438259 | 2002 |