Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis. 31296961 2020
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE In our current work, we examined the miRNA-152 and DNMT-1 expression in chronic liver disease (CLD) due to HCV genotype 4 infection with/without cirrhosis and HCC patients as an attempt to evaluate the potential benefits of these new circulating, noninvasive, prognostic, epigenetic markers for liver cirrhosis and carcinogenesis of Egyptian patients. 31316135 2019
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE Aberrant DNA methylation has been shown to play an important role during carcinogenesis in PDAC, with approximately 80% of tumor overexpressing the DNA methyltransferase 1 (DNMT1) protein. 30385365 2019
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE The DNA methyltransferase 1 (DNMT1)/miR-34a axis promoted carcinogenesis of various types of cancers. 31781245 2019
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells. 29721170 2018
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE We previously reported that reduction of histone marks regulated by DNMT1 following epidrug (5-Azacitidine, 5-Aza) treatment controls induction of epithelial to mesenchymal (EMT) and a cancer stem cell (CSC) phenotype, which facilitates tumorigenesis in PCa cells. 29236331 2018
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE While the deregulated activation of DNMT1 or KIT has been implicated in lung cancer pathogenesis, whether and how DNMT1 and KIT orchestrate lung tumorigenesis are unclear. 28869603 2017
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE In conclusion, these findings provided evidence that DNMT1 expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even prognosis. 29221215 2017
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE Single nucleotide polymorphisms (SNPs) of DNA methyltransferases (DNMTs) might influence DNMT enzyme activity associated with tumorigenesis. 27292127 2016
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Our findings suggested that distinctive DNMTs targeted DNA methylation site to their preference sequences, and this targeting might be associated with diverse roles of DNMTs in tumorigenesis. 26254611 2016
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Our results suggest that epigenetic alteration of histone demethylation regulated by reduction of DNMT1 may control induction of EMT and the CSC phenotype, which facilitates tumorigenesis in PCa cells and has important therapeutic implications in targeting epigenetic regulation. 27659015 2016
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Consistent with these findings, RGS6-/- mice treated with CP-31398, a p53-stablizing agent, and/or 5-Aza, a DNMT1 inhibitor, are protected from BBN-induced tumorigenesis. 27713144 2016
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE DNA methyltransferase 1 (DNMT1) mutants display altered methylation patterns that may contribute to oncogenesis. 27487275 2016
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Our findings enrich the complex relationships between miRNA and DNMTs in carcinogenesis and irradiation stress. 25749421 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 GeneticVariation phenotype BEFREE In order to investigate the association between oncogenesis and the distribution of single nucleotide polymorphisms (SNPs) of EZH2, DNMT1, a case-control study on SNPs in TNBC cases from south China was conducted. 26162541 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 PosttranslationalModification phenotype BEFREE Esophageal squamous carcinoma tumorigenesis may be related with hypermethylation of DNMT1 and RASSF1A promoter CpG island due to their high expression and also their hypermethylation. 25886188 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE Results from our study indicate that DNMT1 and 3b were overexpressed and could be involved in gastric tumorigenesis of intestinal histological type in the case of Tunisian patients. 25461380 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE The expression of DNMT3A/B increased at the initial stages of oncogenesis and the expression of DNMT1 and HAT1 decreased at the advanced stages of breast cancer. 25358520 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 PosttranslationalModification phenotype BEFREE Collectively, our results demonstrate that deregulation of DNMT1-associated lncRNAs contributes to aberrant DNA methylation and gene expression during colon tumorigenesis. 26307088 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis. 25908435 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1. 25950085 2015
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE MiR-148a can suppress gastric tumorigenesis through regulating the expression of target genes such as DNA methyltransferase 1(DNMT-1). 24515776 2014
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 AlteredExpression phenotype BEFREE Our findings indicated that the low-level of serum folate and high-expression of DNMT1 protein or mRNA was significantly associated with cervical carcinogenesis. 23888945 2014
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Our results suggest the existence of a novel miR-148a-DNMT1 regulatory circuit and indicate that miR-148a acts as a tumor suppressor during hepatocellular carcinogenesis. 24714841 2014
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
0.300 Biomarker phenotype BEFREE Although DNMT genes are well known in mammals including humans and mice, they are not well studied in avian species, especially the laying hen which is recognized as an excellent animal model for research on human ovarian carcinogenesis. 23613894 2013