|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing FOXM1 inhibited the expression of Nanog, Oct4, and Sox2 in LCSCs by decreasing the expression of ALDH2. in vivo experiment, silencing FOXM1 suppressed tumorigenesis of LCSCs by decreasing the expression of ALDH2.
|
31580537 |
2020 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells.
|
30643464 |
2019 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Correction to: Post-translational modification of OCT4 in breast cancer tumorigenesis.
|
31641242 |
2019 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OCT4 is a transcription factor known for its regulatory roles in stemness, tumorigenesis and stress response.
|
31182783 |
2019 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OCT4, a homeobox transcription factor, is essential for self-renewal of embryonic stem cells, but little is known about the role of OCT4 in non-germ-cell tumorigenesis.
|
30209362 |
2019 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma.
|
30795814 |
2019 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Cripto-1 and OCT4, expressed in stem cells and cancers, play important roles in tumorigenesis.
|
29223130 |
2018 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the role of Oct4 in tumorigenesis and progression of hepatocellular carcinoma (HCC) has not yet been fully elucidated.
|
29901157 |
2018 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Post-translational modification of OCT4 in breast cancer tumorigenesis.
|
29511337 |
2018 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Active histone marks especially H3K4me3 and H3K9acS10p were enriched in the promoter region with very low levels of repressive marks H3K9me3 and H3K27me3 indicating that active histone modifications are the deciding factor in inducing over-expression of OCT4 during breast carcinogenesis.
|
29203199 |
2018 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, the cells demonstrate aberrant accumulation of wild type tumor-suppressor protein p53, indicating its functional inactivation, highly up-regulated levels of onco-protein cMYC and the BTIC marker OCT3/4, along with metabolic switch to glycolysis - suggesting that these changes occurred in the early stages of tumorigenesis.
|
29568390 |
2018 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The OSCC cell line H103 which was able to be reprogrammed into an iPSC like state showed high expression of Oct4, Sox2 and Nanog at late passage and may provide a potential iPSC model to study multi-stage oncogenesis in OSCC.
|
28417059 |
2017 |
|
POU5F1P3
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
All data demonstrated a distinctive expression pattern of OCT4 spliced variants in different types of breast cancer and provide further evidence for the involvement of embryonic genes in carcinogenesis.
|
27814277 |
2017 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our study reveals a novel mechanism by which Oct4 transcriptionally activates NEAT1 via promoter and MALAT1 via enhancer binding to promote cell proliferation and motility, and led to lung tumorigenesis and poor prognosis.
|
28615056 |
2017 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Reprogramming with octamer-binding protein 4 and Jun dimerization protein 2 can inhibit tumorigenesis by switching off BMP7.Stem Cells 2017;35:2115-2128.
|
28782268 |
2017 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Octamer 4 (Oct4), a member of the Pit-Oct-Unc transcription factor family required to maintain self-renewal and pluripotency of embryonic stem cells, has been previously identified to be associated with tumorigenesis and malignant transformation of numerous types of cancer including hepatocellular carcinoma (HCC).
|
28454439 |
2017 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A similar treatment also modulated numerous microRNAs (miRs) including one regulator of Oct4 as well as miRs involved in oncogenesis and/or malignancy, with only a few estrogen-induced miRs.
|
27959387 |
2017 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here we present basic information about the OCT4 gene, its isoforms and pseudogenes besides discussing the current literature in which OCT4 is linked to cancer, emphasizing its roles in tumorigenesis and therapy.
|
27788386 |
2016 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, the mammosphere-formation efficiency (MFE) and the self-renewal capacity in vitro, and oncogenicity in vivo in Twist-positive breast cancer cells are elevated. lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor.
|
26418365 |
2016 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that Oct4+Sox2+ cells may be reprogrammed cancer stem cells inducing oral carcinogenesis.
|
27279579 |
2016 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To understand the molecular mechanism by which OCT4 and GDF3 function in tumorigenesis as well as stemness, we investigated the transcriptional regulation of GDF3 mediated by OCT4 in human embryonic carcinoma (EC) NCCIT cells, which are pluripotent stem cells of TGCTs.
|
27803451 |
2016 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OCT4 and SOX2 are biomarkers of tumorigenesis and early stage OSCC.
|
26211876 |
2016 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this study, we demonstrated how the cleaved intracellular domain of CD44 (CD44ICD) activates stemness factors such as Nanog, Sox2 and Oct4, and contributes to the tumorigenesis of breast cancer.
|
25909162 |
2015 |
|
POU5F1P3
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Through an integrative approach combining our Oct4 chromatin-immunoprecipitation sequencing and ENCODE datasets, we identified the genome-wide binding regions of Oct4 in lung cancer at promoter and enhancer of numerous genes involved in critical pathways which promote tumorigenesis.
|
25609695 |
2015 |
|
POU5F1P3
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Studies revealed that the methylation level in the basal promoter region of OCT3 was associated with OCT3 expression level and tumorigenesis capability in various prostate cancer cell lines.
|
22231567 |
2013 |