Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 AlteredExpression phenotype BEFREE Collectively, our study showed that BRAF-activated noncoding RNA promotes pancreatic cancer tumorigenesis through miR-195-5p/Wnt/β-catenin axis may serve as a potential target for diagnostics and therapeutics in pancreatic cancer. 31769353 2020
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE The human epidermal growth factor receptor 2 (HER2) plays an essential role in the tumorigenesis and tumor progression in cancer. 31829777 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE Furthermore, data from genome-wide mutation analysis from one patient allowed the reconstruction of a sequence of tumorigenesis of leukemia and HS lesions including the acquisition of a putatively activating KRAS frameshift deletion (p.A66fs). 31737984 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE However, the exact role of PKCι in KRAS-mediated pancreatic tumorigenesis is not fully defined. 31230347 2020
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide. 31761320 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE Our group previously identified the guanine nucleotide exchange factor ARHGEF10 in a genomic screen for genes with copy number alterations that may synergize with oncogenic KRAS to promote PDAC carcinogenesis. 31477830 2020
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE The Keap1-Nrf2 axis has a fundamental role in carcinogenesis. 30803422 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE In conclusion, hMLH1 and O6-MGMT promoter methylation are frequently present in AH, and thus considered to be early events in the carcinogenesis of EC, whereas P16 promoter methylation was mainly present in EC, and not in precursor lesions supporting a late event in the carcinogenesis. 30430425 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE To investigate the role of α3β1 in HER2-driven tumorigenesis in vivo, we generated a HER2-driven MMTV-cNeu mouse model of mammary tumorigenesis with targeted deletion of Itga3 (Itga3 KO mice). 31101121 2019
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker phenotype BEFREE Moreover, changes in caveolin-1 play an important role in tumorigenesis and inflammatory processes. 30742851 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE Mutations in EGFR, ERBB2, NRAS, and BRAF are early clonal genomic events during carcinogenesis of lung adenocarcinoma, whereas TP53 and cell mobility, gap junction, and metastasis-related genes may be late events associated with subclonal diversification and neoplastic progression. 31446140 2019
Entrez Id: 406935
Gene Symbol: MIR143
MIR143
0.400 Biomarker phenotype BEFREE MiR-143-3p may suppress tumorigenesis in PDAC by targeting KRAS. 31521891 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 Biomarker phenotype BEFREE Our data highlight a pivotal role of the cooperative interaction between obesity-ensuing HFD and oncogenic KRAS in driving the heightened aerobic glycolysis during pancreatic tumorigenesis and suggest that in addition to directly targeting KRAS and aerobic glycolysis pathway, strategies to target the upstream of KRAS hyperactivation may bear important therapeutic value. 30819189 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE Mutations in KRAS are initiating events in pancreatic carcinogenesis supported by genetically engineered mouse models of the disease. 29079305 2019
Entrez Id: 406986
Gene Symbol: MIR203A
MIR203A
0.400 AlteredExpression phenotype BEFREE In summary, our study determined that miR-203a down-regulation is closely related to tumorigenesis in bladder cancer; thus suggesting that miR-203a is a potential prognostic marker and a potential target in bladder cancer treatment. 30509104 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE Hyperinsulinemia is a risk factor for pancreatic cancer, but the function of insulin in carcinogenesis is unclear, so this study aimed to elucidate the carcinogenic effects of insulin and the synergistic effect with the KRAS mutation in the early stage of pancreatic cancer. 30838710 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE These results reveal the hitherto unknown c-Src/mTORC1/PRC2 axis, which is essential for ErbB2-driven carcinogenesis. 31263101 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE BRAF plays an indispensable role in activating the MEK/ERK pathway to drive tumorigenesis. 31015455 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 Biomarker phenotype BEFREE Correction: Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis. 30375491 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker phenotype BEFREE Ingenuity Pathways Analysis (IPA) identified many cancer related pathways including PTEN, p53, Nrf2 and inflammatory signaling in UVB-irradiation induced carcinogenesis. 30771437 2019
Entrez Id: 857
Gene Symbol: CAV1
CAV1
0.400 Biomarker phenotype BEFREE The role of Cav-1 in tumorigenesis, including dysregulation of cell cycle, apoptosis and autophagy, adhesion, invasion, and metastasis, such as the formation of invadopodia and matrix metalloproteinase degradation  are presented in detail. 31759347 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.400 GeneticVariation phenotype BEFREE The human epidermal growth factor receptor 2 (ERBB2) may harbour somatic mutations that drive breast tumorigenesis. 30456437 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE In contrast, pathogenic variants classically associated with tumorigenesis in genes like TP53 and BRAF are also present in CD but with low incidence (12.5% and 7%). 31717455 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE KRAS mutation at codon 12 and the presence of MAPK/ERK pathway proteins were detected suggesting their association with tumorigenesis of adenomatoid odontogenic tumors. 30294831 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation phenotype BEFREE The inhibition of miR-199b stimulated NSCLC growth and metastasis, while restoration of miR-199b suppressed K-Ras mutation-driven lung tumorigenesis as well as K-Ras-mutated NSCLC growth and metastasis. miR-199b inactivated ERK and Akt pathways by targeting K-Ras, KSR2, PIK3R1, Akt1, and Rheb1. 30987652 2019