CBS deficiency (CBS<sup>+/-</sup>) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS<sup>+/-</sup> mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels.
Our results suggest a beneficial effect of prune extract on hyperhomocysteinemia with reduction of homocysteine level by its conversion on to SAH by S-adenosylhomocysteine hydrolase, which is activated by NAD<sup>+</sup>, a by-product of NAD(P)H: quinone oxydo reductase-1.