Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 GeneticVariation disease BEFREE The MTHFR rs1801133 CT genotype, TT genotype and T allele; the MTHFR rs1801131 AC genotype, CC genotype and C allele; the MTRR rs1801394 GA genotype, GG genotype and G allele; and the MTRR rs162036 AG genotype and AG+GG genotypes were associated with the efficacy of folic acid therapy for HHcy (P<0·05). 29644956 2018
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 Biomarker disease BEFREE Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation. 30024025 2018
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 Biomarker disease BEFREE Methionine synthase reductase (MTRR) plays a major role in hyperhomocysteinemia, a risk factor related to the occurrence of congenital heart defects (CHDs). 24913415 2014
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 GeneticVariation disease BEFREE To conclude, PD cases exhibited hyperhomocysteinemia and MTRR 66 A>G and cSHMT 1420 C>T gene variants were shown to modulate PD risk by altering the homocysteine levels. 24686188 2014
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 GeneticVariation disease LHGDN Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homocysteine (Hcy), can result in hyperhomocysteinemia. 18792976 2008
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 Biomarker disease CTD_human Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. 17369066 2007
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 Biomarker disease CTD_human Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome? 16575899 2006
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 GeneticVariation disease BEFREE The association of variants of the gene encoding methionine synthase reductase (MTRR) with hyperhomocysteinemia, folate and Vitamin B(12) status in kidney graft recipients is unknown. 15135249 2004
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
0.370 Biomarker disease BEFREE Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia. 10484769 1999