Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.360 | GeneticVariation | disease | BEFREE | Methylene-tetrahydrofolate reductase (MTHFR) and paraoxonase 1 (PON1) gene polymorphisms have been associated with hyperhomocysteinemia and oxidative stress increase, that are established cardiovascular risk factors. | 29564841 | 2018 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology. | 27863359 | 2017 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | To investigate the distribution of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms, known to be involved in hyperhomocysteinemia-related cardiovascular risk, in elite athletes. | 26282718 | 2016 | ||||
|
0.360 | Biomarker | disease | BEFREE | PON1 also protects against neurotoxicity associated with hyperhomocysteinemia in mouse models. | 22643843 | 2012 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Our results suggest that PON1 55 and 192 genotypes might have an important role in developing hyperhomocysteinaemia and may also have a role in the pathogenesis of preeclampsia in a Turkish population. | 19454176 | 2009 | ||||
|
0.360 | Biomarker | disease | CTD_human | Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice. | 19028542 | 2009 | ||||
|
0.360 | Biomarker | disease | CTD_human | However, chronic administration of catechin but not quercetin significantly reduced plasma homocysteine levels, attenuated the reduction of the hepatic CBS activity, and restored the decreased paraoxonase-1 gene expression and activity induced by chronic hyperhomocysteinemia. | 17292331 | 2007 | ||||
|
0.360 | AlteredExpression | disease | BEFREE | As hyperhomocysteinemia due to cystathionine beta synthase deficiency is associated with a decreased expression of paraoxonase-1, a major anti-atherosclerotic component secreted by the liver, we aimed to analyze the expression of paraoxonase-1 and cystathionine beta synthase in Down syndrome fetal liver by quantitative real-time reverse transcriptase-polymerase chain reaction. | 16806076 | 2006 |