Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis. 30622285 2019
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE AML-associated loss-of-function mutations of <i>MIR142</i> disrupt this negative signaling pathway, resulting in sustained <i>HOXA9/A10</i> expression in myeloid progenitors/myeloblasts and ultimately contributing to leukemic transformation.<b>Significance:</b> These findings provide mechanistic insights into the role of miRNAs in leukemogenesis and hematopoietic stem cell function.<i></i>. 29724719 2018
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis. 30270123 2018
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE Hoxa9 and Meis1 also cooperate to induce aggressive AML with high Flt3 expression in mice, suggesting an important role for Flt3 in Hoxa9/Meis1-induced leukemogenesis. 27617578 2017
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Here, we provide evidence of phenotypic and functional hierarchy in MN1-induced leukemic cells, characterise contributions of Hlf, Hoxa9 and Meis1 to in vitro leukemic properties, and reveal Meis2 as a novel player in MN1-induced leukemogenesis. 28960191 2017
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias. 28229434 2017
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE We demonstrate that NUP98-HOXA9 interacts with mixed lineage leukemia (MLL) via this FG repeat domain and that, in the absence of MLL, NUP98-HOXA9-induced cell immortalization and leukemogenesis are severely inhibited. 28210005 2017
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE Functional relevance of GPR56 expression was validated in mice, in which co-expression of Gpr56 significantly accelerated HOXA9-induced leukemogenesis and vice versa knockdown of Gpr56 delayed onset of HOXA9/MEIS1-induced AML. 27063597 2016
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE We analyzed global DNA binding of MEIS1 in leukemic cells as well as gene expression alterations in MEIS1-deficent cells and identified synaptotagmin-like 1 (Sytl1, also known as Slp1) as the MEIS1 target gene that cooperates with Hoxa9 in leukemogenesis. 27018596 2016
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE In many cases, HOXA9 has been shown to be necessary for maintaining leukemic transformation; however, the molecular mechanisms through which it promotes leukemogenesis remain elusive. 26028034 2016
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Homeobox genes HOXA9 and MEIS1 are evolutionarily conserved transcription factors with essential roles in both hematopoiesis and leukemogenesis. 26059450 2015
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE In addition, the N-terminus was required for proliferation and leukemogenesis in vitro and in vivo through upregulation of HoxA9, HoxA10 and Meis2. 25401736 2014
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Collectively, our data suggest that PBX3 is a critical cofactor of HOXA9 in leukemogenesis, and targeting their interaction is a feasible strategy to treat presently therapy resistant CA-AML (eg, MLL-rearranged leukemia) in which HOXA/PBX3 genes are overexpressed. 23264595 2013
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE As both HLX1 and HOXA9 are oncogenes implicated in leukemogenesis, we discuss the implications that the collaboration between Homeobox proteins and PRCs has for senescence and cancer. 24067365 2013
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE Low expression of miR-196b enhances the expression of BCR-ABL1 and HOXA9 oncogenes in chronic myeloid leukemogenesis. 23894305 2013
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE Moreover, we identified PBX2, a well-known homeodomain protein whose aberrant expression enhances HoxA9-dependent leukemogenesis, as a novel let-7c target that may contribute to the AML phenotype. 22964640 2013
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis. 24051379 2013
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE In the current study, we identified Hoxa7, Hoxa9 and Hox cofactor Meis1 as AP-2α target genes, which are involved in myeloid leukemogenesis. 23660297 2013
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Collectively, our data indicate that both truncated and full-length forms of HOXA9 are highly expressed in human MLL-rearranged leukemia, and the truncated isoform of HOXA9 might also play an oncogenic role by cooperating with canonical HOXA9 in cell transformation and leukemogenesis. 22633751 2012
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 AlteredExpression disease BEFREE Forced expression of miR-196b significantly delays MLL-fusion-mediated leukemogenesis in primary bone marrow transplantation through suppressing Hoxa9/Meis1 expression. 22353710 2012
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Collectively, we revealed a MLL-fusion/MYC/LIN28⊣miR-150⊣FLT3/MYB/HOXA9/MEIS1 signaling circuit underlying the pathogenesis of leukemia, where miR-150 functions as a pivotal gatekeeper and its repression is required for leukemogenesis. 23079661 2012
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. 21467841 2011
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Our results show that major differentiation factors of the NK-cell lineage, including HOXA9, HOXA10 and ID2, were (de)regulated via PRC2 which therefore contributes to T-cell leukemogenesis. 20565746 2010
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 Biomarker disease BEFREE Together, these results suggest that specific recruitment of MLL1 requires multiple interactions and is a precondition for stable recruitment of MLL1 fusion proteins to HoxA9 in leukemogenesis. 20541448 2010
Entrez Id: 3205
Gene Symbol: HOXA9
HOXA9
0.100 GeneticVariation disease BEFREE The NUP98-HOXA9 fusion gene with t(7;11)(p15;p15) was identified and revealed to be essential for leukemogenesis and myeloproliferative disease. 19338047 2009