Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 64798
Gene Symbol: DEPTOR
DEPTOR
0.010 Biomarker disease BEFREE Thus, DEPTOR reactivation via a variety of means would have therapeutic potential for the treatment of prostate cancer. 31685947 2020
Entrez Id: 574470
Gene Symbol: MIR525
MIR525
0.010 Biomarker disease BEFREE Mechanism dissection showed that the AR could differentially alter the expression of the VM marker SLPI through miR-525-5p to regulate SLPI; moreover, it could either increase miR-525-5p transcription in PCa or decrease it in BCa via binding to different androgen-response-elements (AREs) located at different positions in the miR-525 precursor promoter. 31843555 2020
Entrez Id: 84525
Gene Symbol: HOPX
HOPX
0.010 AlteredExpression disease BEFREE The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth. 31222811 2020
Entrez Id: 23064
Gene Symbol: SETX
SETX
0.010 Biomarker disease BEFREE A total of 112 patients with diagnosed PCa underwent 2 prostate MRI examinations (Scan1 and Scan2) performed on the same day. 31703155 2020
Entrez Id: 11328
Gene Symbol: FKBP9
FKBP9
0.010 AlteredExpression disease BEFREE The expression of FKBP9 was localized in the cytoplasm, which in normal prostate tissues was obviously lower than that in PCa tissues (P = 0.001). 31780055 2020
Entrez Id: 440400
Gene Symbol: RNASEK
RNASEK
0.010 Biomarker disease BEFREE Recent evidence suggests that the mRNA levels of the RNASEK gene possess biomarker attributes in patients with prostate cancer. 31200028 2020
Entrez Id: 64789
Gene Symbol: EXO5
EXO5
0.010 Biomarker disease BEFREE CRISPR elimination of EXO5 in a PCa cell line impaired homology-directed recombination repair (HDR) and caused androgen-induced genomic instability, as indicated by frequent occurrence of the oncogenic fusion transcript TMPRSS2-ERG. 31616062 2020
Entrez Id: 266700
Gene Symbol: BMP6P1
BMP6P1
0.010 AlteredExpression disease BEFREE Mechanism dissection revealed that R-2HG could increase circRNA-51217 expression to increase the sponge miRNA-646, which might then lead to increase TGFβ1 expression and thus induce TGFβ1/p-Smad2/3 signaling to increase PCa cell invasion. 31846689 2020
Entrez Id: 57214
Gene Symbol: CEMIP
CEMIP
0.010 AlteredExpression disease BEFREE Long non‑coding RNA HCP5 promotes prostate cancer cell proliferation by acting as the sponge of miR‑4656 to modulate CEMIP expression. 31746434 2020
Entrez Id: 23604
Gene Symbol: DAPK2
DAPK2
0.010 AlteredExpression disease BEFREE Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer. 31838085 2020
Entrez Id: 724102
Gene Symbol: SNHG4
SNHG4
0.010 AlteredExpression disease BEFREE SNHG4 was highly expressed in PCa and its upregulation was induced by transcription factor SP1. 31608997 2020
Entrez Id: 2972
Gene Symbol: BRF1
BRF1
0.010 AlteredExpression disease BEFREE Consistent with our clinical observations, BRF1 overexpression in a Pten-deficient mouse (Pten<sup>Δ/Δ</sup> BRF1<sup>Tg</sup>) prostate cancer model accelerated prostate carcinogenesis and shortened survival. 31740786 2020
Entrez Id: 100302158
Gene Symbol: MIR1231
MIR1231
0.010 AlteredExpression disease BEFREE Taken together, our results indicate that miR-1231 expression plays a tumor-suppressive role in prostate cancer. 31822000 2020
Entrez Id: 7486
Gene Symbol: WRN
WRN
0.010 GeneticVariation disease BEFREE The WRN protein along with ATM, BRCA1, BRCA2, and RAD51 among others, comprise a DNA repair system by homologous recombination, and its alterations are associated with forms of hereditary PCa. 31831298 2020
Entrez Id: 79893
Gene Symbol: GGNBP2
GGNBP2
0.010 Biomarker disease BEFREE Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells. 31797427 2020
Entrez Id: 100507347
Gene Symbol: VIM-AS1
VIM-AS1
0.010 Biomarker disease BEFREE Long non-coding RNA VIM-AS1 promotes prostate cancer growth and invasion by regulating epithelial-mesenchymal transition. 31786880 2020
Entrez Id: 25821
Gene Symbol: MTO1
MTO1
0.010 AlteredExpression disease BEFREE Circular RNA-mitochondrial tRNA translation optimization 1 expression was downregulated in tumor tissue compared with paired adjacent tissue (P < .001) in patients with prostate cancer. 31713278 2020
Entrez Id: 8896
Gene Symbol: BUD31
BUD31
0.010 Biomarker disease BEFREE BUD31, a novel co-regulator with FxxLF motif, has been demonstrated to suppress wild-type and mutated AR-mediated prostate cancer growth. 31057123 2020
Entrez Id: 54738
Gene Symbol: FEV
FEV
0.010 GeneticVariation disease BEFREE Prostatic carcinoma with neuroendocrine differentiation harboring the EWSR1-FEV fusion transcript in a man with the WRN G327X germline mutation: A new variant of prostatic carcinoma or a member of the Ewing sarcoma family of tumors? 31831298 2020
Entrez Id: 4784
Gene Symbol: NFIX
NFIX
0.010 Biomarker disease BEFREE Further, results from liquid chromatography-mass spectrometry (LC-MS) showed that the co-factors of AR in PCa and BCa are NFIX and HDAC2, respectively. 31843555 2020
Entrez Id: 406974
Gene Symbol: MIR197
MIR197
0.010 Biomarker disease BEFREE Upregulation of Circular RNA Itchy E3 Ubiquitin Protein Ligase Inhibits Cell Proliferation and Promotes Cell Apoptosis Through Targeting MiR-197 in Prostate Cancer. 31694481 2020
Entrez Id: 90668
Gene Symbol: CARMIL3
CARMIL3
0.010 AlteredExpression disease BEFREE Through bioinformatic metadata analysis, we find that high CARMIL3 expression correlates with poor survival of patients with breast and prostate cancer. 31694931 2020
Entrez Id: 51773
Gene Symbol: RSF1
RSF1
0.010 Biomarker disease BEFREE The positive association of RSF1 protein detection with deletion of 3p13, 10q23 (PTEN), 12p13, 16q23, and 17p13 (<i>p</i> < .0001 each) suggest a role of high RSF1 expression in the development of genomic instability.<b>Conclusion:</b> In summary, the results of our study identify RSF1 as an independent prognostic marker in prostate cancer with a particularly strong role in ERG negative cases. 31687881 2020
Entrez Id: 10190
Gene Symbol: TXNDC9
TXNDC9
0.010 Biomarker disease BEFREE TXNDC9 promotes PCa cell survival and proliferation. 31477836 2020
Entrez Id: 23013
Gene Symbol: SPEN
SPEN
0.010 Biomarker disease BEFREE SHARP hypofractionated stereotactic radiotherapy for localized prostate cancer: a biochemical response to treatment. 31786881 2020