Gene: HNF1B ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis. 20203524 2010
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. 26443449 2015
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA. 30410027 2018
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Multiple newly identified loci associated with prostate cancer susceptibility. 18264097 2008
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. 19767753 2009
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. 26034056 2015
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. 20676098 2010
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes. 21499250 2011
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa. 23464444 2012
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 31562322 2019
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. 18696045 2008
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. 17603485 2007
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk. 21576123 2011
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE The examined HNF1B variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types. 20526366 2010
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 27262462 2016
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE These findings indicate that the HNF1B variants are directly associated with both diabetes and prostate cancer, that diabetes does not mediate these gene variant-prostate cancer relationships, and the relationship between these diseases is not mediated through these gene variants. 19998368 2010
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. 17603485 2007
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies. 26214421 2015
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Genome-wide association scan for variants associated with early-onset prostate cancer. 24740154 2014
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. 18758462 2008
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2016
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease BEFREE A mediation analysis of 9,065 PCa cases and 9,526 controls failed to produce evidence that diabetes mediates the association of the HNF1B locus with PCa risk. 23193118 2012
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Multiple loci identified in a genome-wide association study of prostate cancer. 18264096 2008
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B 		0.200 GeneticVariation disease GWASCAT Two susceptibility loci identified for prostate cancer aggressiveness. 25939597 2015