Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE BRCA2 carriers had an SIR of 4.45 (95% confidence interval [CI] 2.99-6.61) and absolute PCa risk of 27% (95% CI 17-41%) and 60% (95% CI 43-78%) by ages 75 and 85 yr, respectively. 31495749 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive PCa. 31723001 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE BRCA2 mutation increases the risks of aggressive PCa and other cancer types in Japanese males. 31631483 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE After 3 yr of screening, compared with noncarriers, BRCA2 mutation carriers were associated with a higher incidence of PrCa, younger age of diagnosis, and clinically significant tumours. 31537406 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE Survival and cell-cycle alterations were performed after drug treatments in isogenic DT40, DLD1, and OVCAR cell lines with BRCA1, BRCA2, or PALB2 deficiencies and in organoids cultured from prostate cancer patient-derived xenografts with BRCA2 loss. 31409613 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE BRCA2 and Other DDR Genes in Prostate Cancer. 30871108 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE We developed a 3-color FISH assay to detect genomic deletions of BRCA2 and RB1 in prostate cancer cells and patient-derived mCRPC organoids. 31796516 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE Molecular testing determined that his t-NEPC tumor (but not his original adenocarcinoma) harbored complete copy number loss of BRCA2, as well as copy number loss of another HR gene - ataxia telangiectasia, mutated (ATM). 31565603 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Moreover, BRCA2-mutant tumours commonly show the concurrent presence of the intraductal carcinoma of the prostate (IDCP) pathology, a poor prognostic indicator. 30808988 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Association with PCa risk was statistically significant for variants in BRCA2 (P < 0.001, OR = 5.65, 95% CI = 3.55-9.32), HOXB13 (P < 0.001, OR = 4.73, 95% CI = 2.84-8.19), and ATM (P < 0.001, OR = 2.86, 95% CI = 1.63-5.15). 31214711 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Significantly, pathogenic BRCA2 mutations in men with localized early stage PCa increased the risk of distant metastasis. 30542053 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Our findings provide a rationale for the future use of immune oncological approaches in BRCA2-mutated prostate cancer and may encourage efforts to target immunosuppressive T-cell populations to prime tumors for immunotherapy. 31549213 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. 29802810 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Subsequent BRCA2 mutation studies have shown an association with PCa risk and mortality. 30900310 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE SPA-induced DSBs were accentuated in BRCA2-deficient PCs, and combining SPA with PARP or DNA-PKcs inhibition further repressed growth. 31310591 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE To our knowledge, we are the first to report the germline BRCA2 mutation c.4211C>G (p.Ser1404Ter) in prostate cancer. 29580149 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE As breast and prostate cancer share genetic risk factors, including rare, high-risk mutations (eg, in BRCA2), we hypothesized that some of these heritable methylation marks might also be associated with the risk of prostate cancer. 30133758 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Protein-truncating mutations in BRCA2 and BRIP1 were discovered in African American men diagnosed with early-onset prostate cancer. 29356034 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Previous studies have suggested that BRCA2-mutated PC is associated with a more aggressive phenotype and poor prognosis. 28049253 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Mutations in BRCA2 and taxane resistance in prostate cancer. 28676659 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. 28448241 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition and aggressiveness. 28280302 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE In addition, BRCA2 modulation may be a strategy to partially reverse docetaxel resistance in prostate cancer. 28928839 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Therefore, the use of BRCA2 mutation as a clinical prognostic factor could help stratify the high-risk patients and provide clinical strategies for more effective targeted treatments for patients with prostate cancer. 28410213 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE Increased risk of prostate cancer (PCa) is observed in men with BRCA1/BRCA2 mutations. 28812325 2017