Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 GeneticVariation disease GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 AlteredExpression disease BEFREE In addition, the present results indicate that TRAF2 affects TRAIL-induced apoptosis in prostate cancer DU-145 cells via regulating cleaved Caspase-8 and c-Flip expression. 28855498 2017
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 GeneticVariation disease BEFREE Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 × 10(-6)]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues. 26740556 2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 Biomarker disease BEFREE The andean anticancer herbal product BIRM causes destabilization of androgen receptor and induces caspase-8 mediated-apoptosis in prostate cancer. 27705939 2016
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 GeneticVariation disease BEFREE In our meta-analysis, ethnic-specific differences were evident in the association of CASP8 -625 6N del and D302H polymorphisms with PCa risk. 25292051 2014
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 GeneticVariation disease BEFREE Carriers of either the CASP8 or the CASP10 variants were underrepresented in the prostate cancer series (P = 0.02). 21396839 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 GeneticVariation disease BEFREE These results suggested that the CASP 8 IVS12-19G/A and CASP 9 -1263 polymorphism may be involved in etiology of CaP and thus could be implicated as a marker for genetic susceptibility in North Indian population. 21396853 2013
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 Biomarker disease BEFREE In this study, we show that sHA is a potent inhibitor of prostate cancer. sHA blocked the proliferation, motility, and invasion of LNCaP, LNCaP-AI, DU145, and LAPC-4 prostate cancer cells, and induced caspase-8-dependent apoptosis associated with downregulation of Bcl-2 and phospho-Bad. sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor κB (NFκB) activation, and VEGF expression. 21555367 2011
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 GeneticVariation disease BEFREE Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma. 20033885 2010
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 AlteredExpression disease BEFREE In addition to activating the caspase-8-dependent extrinsic apoptosis pathway, we observed that Bcl-X(L) overexpression inhibited triterpenoid-mediated killing of prostate cancer cell line Du145, suggesting that the intrinsic pathway (via mitochondria) also participates in triterpenoid-mediated killing. 18413762 2008
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 AlteredExpression disease BEFREE We have examined caspase-8 activity, BID cleavage, Akt activity, mitochondrial membrane potential (DeltaPsi(m)) and apoptosis in prostate cancer (LNCap, PC-3, PC-3M and DU145) cells treated with or without TRAIL. 11593415 2001
Entrez Id: 841
Gene Symbol: CASP8
CASP8
0.200 Biomarker disease BEFREE Sulindac sulfide up-regulated DR5 and activated the proximal caspase 8 in various different colon and prostate cancer cell lines. 11559570 2001