Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 GeneticVariation disease BEFREE Based on data from genome‑wide association study of the Consortium for Chinese Consortium for Prostate Cancer Genetics, rs1815009 and rs2684788 inside 3'UTR of insulin‑like growth factor 1 receptor (IGF1R) presented significant genotype distribution between PCa and control samples. 30365147 2019
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE IGF1R and AXL were identified as potential targets of miR-139 based on multiple miRNA-binding sites in 3'-untranslated regions of both the genes and their association with prostate cancer growth pathways. 31269290 2019
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 AlteredExpression disease BEFREE The NEAT1, SRC3, and IGF1R were highly expressed in the patients' samples of prostate cancer. 29225160 2018
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Collectively, we proposed a novel model for an IDH1R132H-microRNAs-IGF1R regulatory axis, which might provide insight into the function of IDH1R132H in PCa development. 29331887 2018
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.300 GeneticVariation disease BEFREE Among five analyzed genetic variants, rs11568818 in MMP-7 appeared to be correlated with 2-fold increased prostate cancer risk (OR = 2.39, 95% CI = 1.19-4.82, p = 0.015). 30036379 2018
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Prostate carcinoma is highly dependent on the IGF/IGF-IR/IRS axis. 30338032 2018
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Our study demonstrates that antrocin sensitizes PCa to radiation through constitutive suppression of IGF-1R downstream signaling, revealing that it can be developed as a potent therapeutic agent to overcome radioresistant PCa. 30602706 2018
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.300 GeneticVariation disease BEFREE Meta-analysis showed no associations between MMP1 rs1799750, MMP2 rs243865, or MMP7 rs11568818 and prostate cancer risk overall. 30464622 2018
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.300 AlteredExpression disease BEFREE We conclude that MMP3 and MMP7 activity is different in PCa compared to BPH due to fine regulation by their inhibitor TIMP1. 28471417 2017
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE It is well known that Src tyrosine kinase, insulin-like growth factor 1 receptor (IGF-IR), and focal adhesion kinase (FAK) play important roles in prostate cancer (PrCa) development and progression. 27232975 2017
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone. 28447314 2017
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status. 28545426 2017
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.300 Biomarker disease BEFREE Host derived MMP-7 has previously been shown to support the growth of bone metastatic breast and prostate cancer. 28241871 2017
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.300 Biomarker disease BEFREE IL-17 induced MMP7 and EMT in human prostate cancer LNCaP, C4-2B and PC-3 cell lines, while small interfering RNA knockdown of MMP7 inhibited IL-17-induced EMT. 27375020 2017
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 AlteredExpression disease BEFREE The insulin-like growth factor-1 receptor (IGF1R) plays a key role in cell growth and tumorigenesis, and is overexpressed in most malignancies, including prostate cancer. 27285981 2016
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. 26452103 2015
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.300 Biomarker disease BEFREE Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior. 24833109 2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Our study underscores the oncogenic impact of IGF1R including significant effects on tumor growth, cell migration, sensitivity to apoptotic/chemotherapeutic agents and angiogenesis, and characterizes the INSR, in particular the isoform INSRA, as additional cancer-promoting receptor in prostate cancer. 24809298 2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE To ascertain the biological significance of this hypothesis, we focused on IGF1R, a known prostate cancer growth factor that is induced by androgen and directly targeted by the miR-99a/let7c/125b-2 cluster. 23503464 2014
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE IGF2 mRNA but not IGF2 receptor mRNA expression was increased in patient samples during progression to castrate-resistant PC as was immunoreactivity to INSR and IGF1R antibodies. 23319492 2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth factor receptor (IGF1R), and crosstalk between these two signaling pathways have been implicated in the development of radiation resistance in PC. 23950876 2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Proportional hazard models were used to assess PTEN expression and its interaction with IGF-IR, in relation to lethal prostate cancer (cancer-specific death or distant metastases). 23983239 2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 AlteredExpression disease BEFREE The miRNA let-7a1 inhibits the expression of insulin-like growth factor 1 receptor (IGF1R) in prostate cancer PC-3 cells. 23974362 2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 PosttranslationalModification disease BEFREE IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells. 23152410 2012
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.300 Biomarker disease BEFREE Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer. 22495974 2012