×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
AlteredExpression
disease
BEFREE
Given that etanercept can be used to successfully treat SJS/TEN and TNF -alpha levels are elevated in TSS , if a dermatologist chooses to treat TEN with etanercept, consideration of TSS on the differential should not necessarily exclude etanercept as a reasonable treatment option.
30175438
2018
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
Biomarker
disease
BEFREE
Using a matrigel invasion assay, we showed that TSS significantly attenuated invasive rates in TNF-α -stimulated LNCaP prostate carcinoma cells.
25168152
2014
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
Biomarker
disease
CTD_human
Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects.
20054000
2010
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
Biomarker
disease
RGD
[The effect of transmembrane- and secreted-tumor necrosis factor-alpha on shock liver].
12622907
2002
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
AlteredExpression
disease
BEFREE
Major histocompatibility complex (MHC) class II engagement by toxic shock syndrome toxin 1 (TSST-1) transduces signals leading to proinflammatory cytokine gene expression (tumor necrosis factor alpha [TNF-alpha]) in human monocytes.
10603377
2000
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
AlteredExpression
disease
BEFREE
Although intact TSST1 causes lethal shock in vivo, the individual domains of this molecule may have therapeutic potential: the N-terminal domain to antagonize lymphocyte activation and TNF release during acute TSST1-precipitated toxic shock syndrome , and the C-terminal domain to stimulate antitumor responses without MHC II binding.
9551921
1998
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.540
Therapeutic
disease
RGD
Platelet activating factor (PAF) and tumor necrosis factor-alpha (TNF alpha) interactions in endotoxemic shock: studies with BN 50739, a novel PAF antagonist.
2213560
1990
×
Entrez Id:
4843
Gene Symbol:
NOS2
NOS2
0.500
Biomarker
disease
RGD
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
16601845
2006
×
Entrez Id:
4843
Gene Symbol:
NOS2
NOS2
0.500
Biomarker
disease
CTD_human
Expression of inducible nitric oxide synthase in failing and non-failing human heart.
8745224
1996
×
Entrez Id:
3122
Gene Symbol:
HLA-DRA
HLA-DRA
0.300
Biomarker
disease
CTD_human
Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
28771573
2017
×
Entrez Id:
358
Gene Symbol:
AQP1
AQP1
0.300
Biomarker
disease
CTD_human
Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis.
24028651
2013
×
Entrez Id:
728
Gene Symbol:
C5AR1
C5AR1
0.300
Biomarker
disease
CTD_human
Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a.
18063050
2008
×
Entrez Id:
2638
Gene Symbol:
GC
GC
0.300
Biomarker
disease
CTD_human
Comparison of rocket and crossed immuno-electrophoresis assays for determination of the level of actin complexing of Gc globulin.
17852808
2007
×
Entrez Id:
6402
Gene Symbol:
SELL
SELL
0.200
Biomarker
disease
RGD
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.
19375498
2009
×
Entrez Id:
3162
Gene Symbol:
HMOX1
HMOX1
0.200
Biomarker
disease
RGD
Protective effects of hemin pretreatment combined with ulinastatin on septic shock in rats.
18208666
2008
×
Entrez Id:
1991
Gene Symbol:
ELANE
ELANE
0.200
Therapeutic
disease
RGD
Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats.
18323746
2008
×
Entrez Id:
4282
Gene Symbol:
MIF
MIF
0.200
Biomarker
disease
RGD
[Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats].
17565848
2007
×
Entrez Id:
4282
Gene Symbol:
MIF
MIF
0.200
Biomarker
disease
RGD
Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression.
17381395
2007
×
Entrez Id:
133
Gene Symbol:
ADM
ADM
0.200
Biomarker
disease
RGD
The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway.
17766482
2007
×
Entrez Id:
133
Gene Symbol:
ADM
ADM
0.200
Biomarker
disease
RGD
Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock.
17318497
2007
×
Entrez Id:
2026
Gene Symbol:
ENO2
ENO2
0.200
Biomarker
disease
RGD
[Changes of serum neuron specific enolase in rats with septic shock].
17083782
2006
×
Entrez Id:
887
Gene Symbol:
CCKBR
CCKBR
0.200
Biomarker
disease
RGD
Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats.
15948246
2005
×
Entrez Id:
6915
Gene Symbol:
TBXA2R
TBXA2R
0.200
Therapeutic
disease
RGD
Protective effects of BAY U 3405, a thromboxane A2 receptor antagonist, in endotoxin shock.
7816742
1995
×
Entrez Id:
4158
Gene Symbol:
MC2R
MC2R
0.200
Biomarker
disease
RGD
Metallothionein and zinc metabolism in endotoxin shock rats.
2822467
1987
×
Entrez Id:
2
Gene Symbol:
A2M
A2M
0.200
Therapeutic
disease
RGD
Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock.
2424486
1986