Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 GeneticVariation disease BEFREE This study indicates that a patient's OPRK1 genotype could be used to identify a subset of individuals for whom vaccine treatment may be an effective pharmacotherapy for cocaine dependence. 23995774 2013
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 GeneticVariation disease BEFREE Here, we examined whether the OPRK1 rs6989250 C>G affects stress-induced cocaine craving and cortisol responses, subsequent cocaine relapse risk and the neural response to stress using functional magnetic resonance imaging (fMRI) in cocaine dependence. 23962922 2013
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease CTD_human Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. 18575850 2008
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease CTD_human Regulation of cocaine-reinstated drug-seeking behavior by kappa-opioid receptors in the ventral tegmental area of rats. 20232055 2010
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease BEFREE Some analogues maintain a KOR agonist/MOR partial agonist profile, which is being explored in the development of a treatment for cocaine addiction. 31779072 2019
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease PSYGENET Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). 17622222 2008
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease PSYGENET Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583 1996
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease PSYGENET Here, we examined whether the OPRK1 rs6989250 C>G affects stress-induced cocaine craving and cortisol responses, subsequent cocaine relapse risk and the neural response to stress using functional magnetic resonance imaging (fMRI) in cocaine dependence. 23962922 2013
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease PSYGENET This study indicates that a patient's OPRK1 genotype could be used to identify a subset of individuals for whom vaccine treatment may be an effective pharmacotherapy for cocaine dependence. 23995774 2013
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease BEFREE Further modification of this pendant resulted in retention of KOR agonism and the addition of mu opioid receptor (MOR) partial agonism, a bifunctional profile with potential to be used in the treatment of cocaine addiction. 31199621 2019
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease PSYGENET Evidence suggests that the kappa-opioid receptor (KOP-r) system plays an important role in cocaine addiction. 17532787 2007
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 AlteredExpression disease BEFREE Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583 1996