Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 GeneticVariation disease BEFREE We examined the influence of functional genetic variants in DAT1 on cocaine addiction. 16537431 2006
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 GeneticVariation disease BEFREE Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD. 20170711 2010
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 GeneticVariation disease BEFREE Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively. 19462300 2009
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 GeneticVariation disease BEFREE Association between the Intron 8 VNTR Polymorphism of the DAT1 Gene and Crack Cocaine Addiction. 29332099 2017
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease CTD_human Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. 19602552 2009
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554 2010
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease BEFREE These data describe the behavioral consequence of cocaine tolerance, provide a putative mechanism for its development, and suggest that compounds that disperse DAT complexes may be efficacious treatments for cocaine addiction. 29175958 2018
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease CTD_human We examined the influence of functional genetic variants in DAT1 on cocaine addiction. 16537431 2006
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease PSYGENET Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively. 19462300 2009
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease CTD_human Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. 11746736 2002
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease BEFREE Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583 2010
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583 2010
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease PSYGENET Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD. 20170711 2010
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease PSYGENET Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. 21150910 2011
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease BEFREE Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. 20505554 2010
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease BEFREE The successful intervention into alcohol dependence and craving brought about by baclofen in both human and animal studies elucidates glutamatergic mechanisms in alcoholism whereas the role of the dopamine transporter, in conjunction with both the noradrenergic and serotonergic transporters, are implicated in cocaine dependence and craving. 15545018 2004
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Therapeutic disease CTD_human Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. 11746736 2002
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Therapeutic disease CTD_human Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. 19602552 2009
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Therapeutic disease CTD_human We examined the influence of functional genetic variants in DAT1 on cocaine addiction. 16537431 2006
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Therapeutic disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 AlteredExpression disease BEFREE We found that patients with genetically higher DAT levels had better treatment outcomes with disulfiram pharmacotherapy of cocaine dependence than those with lower DAT levels.(Am J Addict 2019;28:311-317). 31087723 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 AlteredExpression disease BEFREE Increased expression of Arc, CDK5 and TH, and decrease in DAT protein levels persisted longer after withdrawal, pointing to a neuroplastic lasting effect similar to that involved in cocaine addiction. 30321610 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 AlteredExpression disease BEFREE <b>Background:</b> Preclinical and clinical data suggest that a compound which binds potently to and inhibits the dopamine transporter, but with a slower onset and offset rate than cocaine and with less abuse potential and psychomotor stimulant activity, could be a useful adjunct in the treatment of cocaine dependence. 30042675 2018