Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE The data showing a strong association of the minor alleles (A1 and B1) of the DRD2 with cocaine dependence suggest that a gene, located on the q22-q23 region of chromosome 11, confers susceptibility to this drug disorder. 8261891 1993
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.300 Biomarker disease CTD_human Brain corticotropin-releasing factor mediates 'anxiety-like' behavior induced by cocaine withdrawal in rats. 7796157 1995
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 AlteredExpression disease BEFREE Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583 1996
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
0.550 Biomarker disease PSYGENET Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583 1996
Entrez Id: 3351
Gene Symbol: HTR1B
HTR1B
0.500 Therapeutic disease CTD_human Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. 9603521 1998
Entrez Id: 3351
Gene Symbol: HTR1B
HTR1B
0.500 Biomarker disease CTD_human Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. 9603521 1998
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR
0.300 Biomarker disease CTD_human The role of cholecystokinin (CCK), CCK-A or CCK-B receptor antagonists in the spontaneous preference for drugs of abuse (alcohol or cocaine) in naive rats. 9922984 1998
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE Moreover, DRD2 alleles are not associated with severity of cocaine dependence in this sample. 10023512 1999
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease BEFREE The DRD2 gene had an independent and additive effect on cocaine dependence. 10523822 1999
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.520 Biomarker disease PSYGENET These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.520 Therapeutic disease CTD_human These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.520 Biomarker disease BEFREE These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
0.520 Biomarker disease CTD_human These findings support a modest role of the DRD3 gene in susceptibility to cocaine dependence. 10523822 1999
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.300 Biomarker disease CTD_human A role for the bed nucleus of the stria terminalis, but not the amygdala, in the effects of corticotropin-releasing factor on stress-induced reinstatement of cocaine seeking. 10516337 1999
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE Using the transmission disequilibrium test, the present study examined linkage disequilibrium of alcohol and drug (opioid and/or cocaine) dependence with three DRD2 polymorphic systems: (a) TaqI A, (b) TaqI D, and (c) the functional -141CIns/Del promoter systems. 11054774 2000
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease CTD_human Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. 10900248 2000
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Therapeutic disease CTD_human Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. 10900248 2000
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.550 Biomarker disease PSYGENET Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766 2000
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.550 Biomarker disease BEFREE Using the human mu opioid receptor gene (OPRM1) as a model system, we have combined these approaches to test a potential role of OPRM1 in substance (heroin/cocaine) dependence. 11092766 2000
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Biomarker disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.600 Therapeutic disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.550 Biomarker disease CTD_human Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. 11320258 2001
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
0.510 Biomarker disease CTD_human Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. 11717377 2001
Entrez Id: 1020
Gene Symbol: CDK5
CDK5
0.310 Biomarker disease PSYGENET Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction. 11268215 2001
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.310 Biomarker disease CTD_human These results suggest that 5-HT2A receptors play an important role in the behavioral effects of cocaine and that 5-HT2A receptors should be considered a viable target for analysis in the search for pharmacotherapies useful in the treatment of cocaine dependence. 11259563 2001