Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE In this same group, interaction analysis demonstrated that the presence of DRD2-T allele and concomitant absence of DRD4-7R allele were associated with risk for crack cocaine addiction. 30367264 2019
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease RGD High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. 29454035 2018
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease BEFREE These heteroreceptor complexes can potentially be targeted for future pharmacotherapy of cocaine addiction by using heterobivalent compounds or A2AR-D2R receptor interface-interfering peptides that disrupt the A2AR-D2R-Sigma1R complexes. 30384981 2018
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease PSYGENET We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P < 0.05) in Caucasian subjects, but not African-American individuals. 24078558 2013
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. 23635803 2013
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE We observed that both DRD1 and DRD2 polymorphisms were associated with opiate and cocaine dependence (P < 0.05) in Caucasian subjects, but not African-American individuals. 24078558 2013
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease PSYGENET Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. 23635803 2013
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease BEFREE Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. 22832851 2012
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease PSYGENET Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability. 22832851 2012
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease PSYGENET We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Therapeutic disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease CTD_human Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. 20494958 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE Our study suggests that there is no association between the DRD2 and DAT1 polymorphisms and CD. 20170711 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease BEFREE Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583 2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease CTD_human D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. 18418874 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Therapeutic disease CTD_human D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats. 18418874 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease CTD_human Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. 16541082 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Therapeutic disease CTD_human Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. 16541082 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Therapeutic disease CTD_human Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. 17332411 2007
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Therapeutic disease CTD_human Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 16971900 2006
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 Biomarker disease CTD_human Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. 16971900 2006
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.800 GeneticVariation disease BEFREE Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample. 16094250 2005