Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 GeneticVariation disease BEFREE These findings have led to the development of recombinant butyrylcholinesterase mutants and viral gene therapy to combat cocaine addiction, along with in-depth studies on the significance of butyrylcholinesterase in obesity. 31702488 2020
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Biomarker disease BEFREE This brief review examines some key phenomena and considers means of modulating BChE as treatments for cocaine addiction, anxiety, aggression, and obesity. 29535625 2018
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Biomarker disease BEFREE Butyrylcholinesterase (BChE) gene therapy is emerging as a promising concept for treatment of cocaine addiction. 25814464 2015
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Butyrylcholinesterase (BChE) gene therapy is emerging as a promising concept for treatment of cocaine addiction. 25814464 2015
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Biomarker disease BEFREE In continuing efforts to develop gene transfer of human butyrylcholinesterase (BChE) as therapy for cocaine addiction, we conducted wide-ranging studies of physiological and metabolic safety. 24892251 2014
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Biomarker disease BEFREE Cocaine hydrolase gene transfer of mutated human butyrylcholinesterase (BChE) is evolving as a promising therapy for cocaine addiction. 24085526 2014
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 GeneticVariation disease BEFREE Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes. 24312228 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 GeneticVariation disease BEFREE Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. 23840704 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. 22935511 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. 22960160 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity. 23000451 2013
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. 20971807 2011
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine. 20060817 2010
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. 18514640 2008
Entrez Id: 590
Gene Symbol: BCHE
BCHE
0.370 Therapeutic disease CTD_human Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction. 18292872 2008