Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | phenotype | BEFREE | Among these ZAP-70 "outliers," those with Ig-mutated CLL had clinical features that are uncharacteristic of this CLL subtype: 2 required early treatment and 2 used a mutated VH3-21 gene, an IgVH gene that has been associated with progressive disease. | 12595313 | 2003 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Risk factors for progressive disease were Rai stage of 1 or higher and unmutated immunoglobulin variable region heavy chain (IgVH). | 19414856 | 2009 | ||||
|
0.070 | GeneticVariation | phenotype | BEFREE | Strikingly, it was also associated with progressive disease within the mutated IGHV gene subset. | 22160382 | 2012 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | CLL is subdivided into two disease subtypes, whereby leukemias with hypermutated immunoglobulin heavy chain variable (IGHV) genes have a more favorable prognosis than those with unmutated IGHV genes, which tend to show advanced, progressive disease, adverse cytogenetic features and resistance to therapy. | 22591389 | 2012 | ||||
|
0.070 | GeneticVariation | phenotype | BEFREE | We investigated the molecular characteristics of 19 SDRPL patients, 5 of them with progressive disease.IGHV genes were mutated in 9/13 (69%). | 26426381 | 2016 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | A high expression of CD49d (>30%) was found in 142/415 (34%) patients and was associated with progressive disease (advanced clinical stage, high serum lactate dehydrogenase or β2 -microglobulin levels; all p < 0·05) and aggressive disease biology (increased ZAP70 or CD38, unmutated IGHV, trisomy 12, mutations of NOTCH1 and SF3B1; all P < 0·05). | 26559905 | 2016 | ||||
|
0.070 | GeneticVariation | phenotype | BEFREE | Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease. | 26847028 | 2016 |