Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
0.060 AlteredExpression phenotype BEFREE Continued androgen receptor (AR) expression and signaling is a key driver in castration-resistant prostate cancer (CRPC) after classical androgen ablation therapies have failed, and therefore remains a target for the treatment of progressive disease. 23861347 2013
Entrez Id: 367
Gene Symbol: AR
AR
0.060 GeneticVariation phenotype BEFREE A missense mutation in the ligand-binding domain of the androgen receptor F876L confers resistance to the second-generation antiandrogens enzalutamide and ARN-509 in preclinical models of AR function and prostate cancer and is detected in plasma DNA from ARN-509-treated patients with progressive disease. 23779130 2013
Entrez Id: 367
Gene Symbol: AR
AR
0.060 AlteredExpression phenotype BEFREE Since the expression of the AR is retained and often increased in progressive disease, AR protein down-regulation is a promising therapeutic approach against prostate cancer. 21796654 2012
Entrez Id: 367
Gene Symbol: AR
AR
0.060 AlteredExpression phenotype BEFREE Here, we hypothesized that progressive disease on abiraterone may occur secondary to glucocorticoid-induced activation of mutated AR. 22411952 2012
Entrez Id: 367
Gene Symbol: AR
AR
0.060 Biomarker phenotype BEFREE These insights suggest that signaling via the androgen receptor (AR) -- either via alternate signaling pathways impinging on the AR or through the in situ formation of androgens within progressive tumors -- is an important contributor to such progressive disease. 18471793 2008
Entrez Id: 367
Gene Symbol: AR
AR
0.060 Biomarker phenotype BEFREE It also has potential in stratifying subsets of patients exhibiting progressive disease associated with dampened AR transcriptional functions who may be targeted by tailored therapeutic strategies. 18245536 2008