Gene: BRCA2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease CLINVAR
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 CausalMutation disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 Biomarker disease HPO
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 CausalMutation disease CLINVAR
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GenomicAlterations disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE 105 BRCA1 carriers and 122 BRCA2 carriers developed breast cancer during follow-up. 24249359 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. 22351618 2012
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE 5%-10% of breast cancer cases are hereditary and are caused by pathogenic mutations in the considered reference BRCA1 and BRCA2 genes. 23586058 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE 506 BRCA1 and 505 BRCA2 mutation carriers with a diagnosis of breast cancer were observed for up to 30 years. 26239694 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer penetrance by age 80 was estimated to be 48% (95% CI 7-82%) for BRCA1 mutation carriers and 74% (7-94%) for BRCA2 mutation carriers. 11044354 2000
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer is a rare disease in men.Germ-line mutations in BRCA2 and androgen receptor (AR) genes are thought to be responsible for a proportion of male breast cancer cases. 11139248 2001
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer occurs rarely in men and risk factors for the disease include germline mutations of the BRCA2 gene. 11948477 2002
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer penetrances were 27% (95% CI 20-34%) at age 50 years and 39% (27-52%) at age 70 in BRCA1 carriers, and 26% (0.18-0.34%) at age 50 and 44% (29-58%) at age 70 in BRCA2 carriers, and ovarian cancer penetrances were 14% (7-22%) at age 50 and 43% (21-66%) at age 70 in BRCA1 carriers and 3% (0-7%) at age 50 and 15% (4-26%) at age 70 in BRCA2 carriers. 15340362 2004
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 Biomarker disease BEFREE Breast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. 16672066 2006
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. 18034184 2007
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 Biomarker disease BEFREE Breast cancer rates were higher for BRCA2 than BRCA1 after testing anonymized samples in this selected population at 65 of 1,000 in study and 36 of 1,000 in total follow-up for BRCA2 compared with 44 of 1,000 and 27 of 1,000 for BRCA1. 19567506 2009
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer in a BRCA2 mutation carrier with a history of prostate cancer. 19787003 2009
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast Cancer 2 gene (BRCA2) mutation carriers have a 45% chance of developing breast cancer and a 11% risk of developing ovarian cancer by the age of 70. 21671020 2011
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer prognosis in BRCA1 and BRCA2 mutation carriers: an International Prospective Breast Cancer Family Registry population-based cohort study. 22147742 2012
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 Biomarker disease BEFREE Breast cancer research has yielded several important results including the strong susceptibility genes,BRCA1 and BRCA2 and more recently 19 genes and genetic loci that confer a more moderate risk.The pace of discovery is accelerating as genetic technology and computational methods improve. 22218795 2012
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer type 1 and 2 (BRCA1 and BRCA2) susceptibility genes are the most common involved genes and confer a 10-30 times higher risk of developing the disease compared to the general population. 23673076 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer is the most common in women worldwide, with some 5-10% of all cases due to inherited mutations of BRCA1 and BRCA2 genes. 24870721 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast carcinomas showed extensive miRNA alteration compared to normal breast tissues in BRCA1 and BRCA2 mutation carriers. 26378051 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer risk conferred by pathogenic variants in non-BRCA1 and non-BRCA2 predisposition genes. 28418444 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.700 GeneticVariation disease BEFREE Breast cancer 2 (BRCA2)-associated breast and ovarian cancers are sensitive to platinum-based chemotherapy. 28608931 2017