Gene: CCND1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE <b>Conclusion</b>: This study demonstrated that the low LPP1 expression in breast cancer cells is associated with high levels of cyclin D1/D3 and MMPs as a result of increased transcription by cFOS and cJUN. 31534541 2019
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 GeneticVariation disease BEFREE Breast cancer drivers (ER and cyclin D1) as well as cancer-signaling nodes (pSrc, c-Myc, and survivin) were demonstrated to be downstream of AGR2. 20525379 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 in breast cancer. 10066068 1998
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer. 10208420 1999
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 (CCND1) amplification is found in 10-15 per cent of invasive breast carcinomas, but it is not well established whether this gene alteration also occurs in the precursor of invasive breast carcinoma, ductal carcinoma in situ (DCIS). 10398079 1999
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1, which is required for cell cycle progression in G1 and has been shown to play an important role in the pathogenesis of breast cancer has been implicated as a possible mediator of such effects. 11110058 2000
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D1 protein overexpression and gene amplification in benign breast tissue and breast cancer risk. 11263590 2001
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 could therefore serve as a possible target in managing breast cancer in the African-American population. 11848520 2002
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide. 12738746 2003
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1, EMS1 and 11q13 amplification in breast cancer. 12755491 2003
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 and p21(Waf1/CIP1) were additionally confirmed as important mediators of CDDO growth inhibition in genetically modified breast cancer cell lines. 14522919 2003
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D1 is a positive cell cycle regulator that is overexpressed in a variety of neoplasms, including mantle cell lymphoma and breast carcinoma. 15578074 2005
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease CTD_human Cyclin D1 gene amplification and chromosome 11 aneusomy were investigated using fluorescence in situ hybridization whereas cyclin D1, PgR, HER-2, Bcl2, p53, and Ki-67 expressions were analyzed by immunohistochemistry in 121 stage I or II breast cancer patients uniformly treated with cyclophosphamide/metotrexate/5-fluorouracil-based chemotherapy. 17255770 2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE CCND1 and EMSY, on 11q13, are frequently amplified in breast cancer. 18393977 2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer. 19915977 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 gene (CCND1) is a critical mitogen-regulated cell-cycle control element whose transcriptional modulation plays a crucial role in breast cancer growth and progression. 20421209 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer. 20429623 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D1 is a mediator of cell-cycle control that is frequently overexpressed in primary ductal breast carcinomas, but its role is controversial. 20530440 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D-1 protein over-expression and/or gene amplification have been shown to be frequent events in subsets of breast carcinomas. 21159451 2011
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE BCL-1 participates in the 11q13 amplification found in breast cancer. 2181375 1990
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D1, the product of the CCND1 gene, is one of the most commonly overexpressed proteins in breast cancer. 22976805 2012
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D1 (CCND1), a key regulator of cell cycle progression, is overexpressed in many human cancers, including breast cancer. 23670132 2013
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion. 23786849 2013
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 AlteredExpression disease BEFREE Cyclin D1 and Dicer expression significantly correlates in luminal A and basal-like subtypes of human breast cancer. 24287487 2013
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		0.500 Biomarker disease BEFREE Cyclin D1 gene amplification is highly homogeneous in breast cancer. 24862872 2016