Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
0.020 GeneticVariation disease BEFREE Allele-specific Primer PCR (ASP-PCR) was recruited in this study to genotype rs13423759 position in 172 breast cancer and 148 healthy control subjects. 30336339 2018
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
0.020 AlteredExpression disease BEFREE Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processes by modulating RNA expression, and acts as an oncogene in breast cancer. 31186064 2019
Entrez Id: 144568
Gene Symbol: A2ML1
A2ML1
0.020 AlteredExpression disease BEFREE The aim of this paper was to evaluate the role of bcl-2 in the susceptibility of the MCF7 ADR human breast carcinoma line overexpressing the P-170 glycoprotein (P-170) to various drugs. 12460791 2002
Entrez Id: 144568
Gene Symbol: A2ML1
A2ML1
0.020 AlteredExpression disease BEFREE An immunochemical analysis of mdm2 expression in human breast cancer and the identification of a growth-regulated cross-reacting species p170. 10211113 1998
Entrez Id: 13
Gene Symbol: AADAC
AADAC
0.010 PosttranslationalModification disease BEFREE In the present study, the results denote some new molecular DAC targets and pathways based on the chemical modification of DNA methylation in breast cancer. 22076154 2011
Entrez Id: 79719
Gene Symbol: AAGAB
AAGAB
0.100 Biomarker disease HPO
Entrez Id: 14
Gene Symbol: AAMP
AAMP
0.010 AlteredExpression disease BEFREE Increased expression of AAMP in breast cancer was observed compared with that in normal tissues (p<0.05). 23564791 2013
Entrez Id: 15
Gene Symbol: AANAT
AANAT
0.030 GeneticVariation disease BEFREE No significant breast cancer associations were found for variants in the AANAT gene. 22138747 2012
Entrez Id: 15
Gene Symbol: AANAT
AANAT
0.030 GeneticVariation disease BEFREE In the main effects analysis, CC carriers of rs4238989 and GG carriers of rs3760138 in the AANAT gene had increased risk of breast cancer, whereas TT carriers of BMAL1 rs2278749 and TT carriers of CLOCK rs3749474 had reduced risk. 23822714 2013
Entrez Id: 15
Gene Symbol: AANAT
AANAT
0.030 GeneticVariation disease BEFREE For combined heterozygotes and rare homozygotes a slightly elevated breast cancer risk was found for rs8150 in gene AANAT (OR 1.17; 95% CI 1.01-1.36), and a reduced risk for rs3816358 in gene ARNTL (OR 0.82; 95% CI 0.69-0.97) in the complete study population. 25229211 2014
Entrez Id: 16
Gene Symbol: AARS1
AARS1
0.010 GeneticVariation disease BEFREE We found significant associations with the risk of breast cancer for rs34087264 in AARS [odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.01-1.31], rs801186 in HARS (OR = 1.29, 95% CI = 1.08-1.54), rs193466 in RARS (OR = 1.17, 95% CI = 1.02-1.35), and rs2273802 in WARS (OR = 1.14, 95% CI = 1.01-1.30). 24510587 2015
Entrez Id: 26574
Gene Symbol: AATF
AATF
0.020 GeneticVariation disease BEFREE Based on its biological function, and direct interaction with several known breast cancer risk factors, AATF is a good candidate gene for being involved in heritable cancer susceptibility. 20025740 2009
Entrez Id: 26574
Gene Symbol: AATF
AATF
0.020 Biomarker disease BEFREE The transcriptional cofactor Che-1 is an RNA polymerase II (Pol II) which is involved in tumorigenesis, such as breast cancer and multiple myeloma. 27012205 2016
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.040 GeneticVariation disease BEFREE Previous studies have reported that liver X receptor (LXR), ATP‑binding cassette sub‑family G number 1 (ABCG1) and ATP‑binding cassette transporter number 1 (ABCA1), which are associated with cholesterol metabolism, may be associated with the development and progression of breast cancer. 31432185 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.040 Biomarker disease BEFREE Moreover, miR-96 may play an oncogenic role in breast cancer by suppressing the apoptosis through the regulation of ABCA1. 28546132 2017
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.040 Biomarker disease BEFREE We further demonstrate that fluidity can be regulated by cellular cholesterol flux, as the cholesterol efflux channel ABCA1 potentiated metastatic behaviors in vitro and in vivo The requirement for fluidity was further supported by the finding in breast cancer patients that ABCA1 was overexpressed in 41% of metastatic tumors, reducing time to metastasis by 9 years. 26825169 2016
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.040 GeneticVariation disease BEFREE Two common SNPs in the distal promoter for membrane-bound (MB) COMT, rs2020917 and rs737865, were associated with breast cancer risk reduction in premenopausal women in the Mayo Clinic study, with allele-specific odds ratios (OR) of 0.70 [95% confidence interval (CI), 0.52-0.95] and 0.68 (95% CI, 0.51-0.92), respectively. 18632656 2008
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.040 AlteredExpression disease BEFREE The expression profile of ATP-binding cassette transporter genes in breast carcinoma. 23556449 2013
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.040 Biomarker disease BEFREE The selective expression of MRP8 (ABCC11), a new member of ATP-binding cassette transporter superfamily could be a molecular target for the treatment of breast cancer. 11591886 2001
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.040 Biomarker disease BEFREE ABCC11 (Multidrug resistance protein 8; MRP8), a plasma membrane ATP-binding cassette transporter, has been implicated in drug resistance of breast cancer by virtue of its ability to confer resistance to fluoropyrimidines and to efflux methotrexate, and by its expression in this tumor. 18310281 2008
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.040 GeneticVariation disease BEFREE Previous studies have reported that liver X receptor (LXR), ATP‑binding cassette sub‑family G number 1 (ABCG1) and ATP‑binding cassette transporter number 1 (ABCA1), which are associated with cholesterol metabolism, may be associated with the development and progression of breast cancer. 31432185 2019
Entrez Id: 10351
Gene Symbol: ABCA8
ABCA8
0.100 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE NF-кB has been linked to doxorubicin resistance in breast cancer patients. 24344116 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE Docetaxel, frequently used for the treatment of breast cancer, is mainly metabolized via hepatic cytochrome P450 (CYP) 3A in humans and is also a substrate of P-glycoprotein (P-gp). 29679509 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker disease BEFREE Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/β-catenin pathway in the clinical chemoresistance of breast cancer. 26876203 2016