Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE In addition, the availability of normal and tumor-derived epithelial cells with known p53 sequences from a single breast cancer patient should facilitate understanding of the p53 regulation in mammary cells. 7923592 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. 27040927 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE In conclusion, we identify IL-6 as a novel non-canonical Notch target gene, and reveal roles for p53 and IKKα/IKKβ in non-canonical Notch signaling in breast cancer and in the generation of cell context-dependent diversity in the Notch signaling output. 23178494 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Clinical studies of p53 in treatment and benefit of breast cancer patients. 10732788 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE In all, 171 patients with breast cancer who had HER2 FISH that had increased mean CEP17 copy numbers (> 2.6) were selected for additional chromosome 17 studies that used probes for Smith-Magenis syndrome (SMS), retinoic acid receptor alpha (RARA), and tumor protein p53 (TP53) genes. 21947821 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE GATA3 mutations were found to be significantly associated with luminal-like breast cancer (P=.002 in the TCGA cohort and P<.001 in the FUSCC cohort), and were highly mutually exclusive to PIK3CA mutations (P=.001 in the TCGA cohort and P=.003 in the FUSCC cohort) and TP53 mutations (P<.001 in both cohorts). 24477928 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. 22392042 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE The prevalence of the most common breast cancer driver abnormalities including TP53 and PIK3CA mutations and MYC and ERBB2 amplifications showed no difference between the two groups. 27811364 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Favorable prognostic impact in loss of TP53 and PIK3CA mutations after neoadjuvant chemotherapy in breast cancer. 24924774 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Using a combination of qRT-PCR, promoter-luciferase, and chromatin-immunoprecipitation assays, we show that p53 brings about down-regulation of miR-191-5p in breast cancer. miR-191-5p overexpression brought about inhibition of apoptosis in breast cancer cell lines (MCF7 and ZR-75) as demonstrated by reduction in annexin-V stained cells and caspase 3/7 activity, whereas miR-191-5p down-regulation showed the opposite. 28450532 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Finally, elevated expression of NMG correlates with mutant p53 status and poor prognosis in breast cancer patients. 26067754 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Breast Cancer (BC) is one of the most common cancers diagnosed in TP53 mutation carriers. 24936644 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE However, the expression profile of LRRC3B had a significant relationship with tissue grade, irrespective of the expressions of PR, CERB-2, VEGF, and Ki67 except in cases of p53 and ER, leading us to a conclusion that the abnormal expression of LRRC3B could serve as a useful marker for diagnosis and prognosis in breast carcinomas. 24839112 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE These data provide a model in which p68 and p53 interplay regulates PLK1 expression, and which describes the behavior of these molecules, and the outcome of their interaction, in human breast cancer. 24626184 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Combination of arabinogalactan and curcumin induces apoptosis in breast cancer cells in vitro and inhibits tumor growth via overexpression of p53 level in vivo. 28152473 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE The TP53 gene has also been associated with breast cancer but to a much more limited extent than BRCA-1. 8880869 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Here we investigate how p53 may affect response to antihormonal treatments, using estrogen-dependent breast cancer cell-lines with different p53 status. 20549698 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting. 27129168 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE TP53 mutations, in particular those affecting the L2/L3 domains, are associated with resistance to anthracycline or mitomycin treatment in breast cancer patients. 23246812 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-κB and p53. 30556250 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Our biologically-based refinements excluded genes that were associated with subtype but not downstream of p53 signaling, and identified a signature for p53 loss that is shared across breast cancer subtypes. 17150101 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Triple‑negative breast cancer (TNBC) is a type of breast cancer that is more aggressive and highly lethal when p53 is mutated. 29568874 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Thus, our results indicate that cancer gene therapy combining two or more tumor suppressors such as p53 and ING4 may constitute a novel and effective therapeutic modality for human breast cancer and other cancers. 26530780 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE However, the significant frequency of mutations in the p53 gene suggest that p53 could be one of the genes involved in the genesis of sporadic breast carcinomas in Indian women. 11029509 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Therefore, we examined the expression of CYPs (CYP2A6, CYP1B1 and CYP3A) and p53 in specimens from 34 Japanese patients with breast cancer by immunohistochemistry. 15769614 2005