Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE GATA3 mutations were found to be significantly associated with luminal-like breast cancer (P=.002 in the TCGA cohort and P<.001 in the FUSCC cohort), and were highly mutually exclusive to PIK3CA mutations (P=.001 in the TCGA cohort and P=.003 in the FUSCC cohort) and TP53 mutations (P<.001 in both cohorts). 24477928 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. 22392042 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE The prevalence of the most common breast cancer driver abnormalities including TP53 and PIK3CA mutations and MYC and ERBB2 amplifications showed no difference between the two groups. 27811364 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Favorable prognostic impact in loss of TP53 and PIK3CA mutations after neoadjuvant chemotherapy in breast cancer. 24924774 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Finally, elevated expression of NMG correlates with mutant p53 status and poor prognosis in breast cancer patients. 26067754 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Breast Cancer (BC) is one of the most common cancers diagnosed in TP53 mutation carriers. 24936644 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting. 27129168 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE TP53 mutations, in particular those affecting the L2/L3 domains, are associated with resistance to anthracycline or mitomycin treatment in breast cancer patients. 23246812 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE All families had previously been found negative for germline BRCA1, BRCA2 and TP53 mutations, together explaining about 23% of hereditary predisposition to breast cancer in our country. 11461078 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE We therefore conclude that mutations in exons 5-7 of p53 gene are rare causes of breast cancer among Bengalee Hindu caste females, and therefore of little help for genetic counseling and diagnostic purposes. 23167364 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Therefore, we investigated the frequency of both exon and intron germ-line p53 base changes in 42 breast cancer patients with a strong family history of breast cancer. 10706125 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE In the present study, we analyzed patients of 19 German families with early onset breast cancer and/or a family history of breast and/or ovarian cancer for the presence of mutations in BRCA1 and TP53. 12505256 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE A number of independent groups using different methods of detection have shown that p53 alterations are associated with more aggressive tumor biologic factors and a poorer prognosis in breast cancer patients. 7819584 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Our finding suggests that TP53 (Arg72Pro) polymorphism may play a significant role as risk factor for breast cancer in north Indian breast cancer patients. 26553387 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE In the present study, we show that, in addition to these well-studied molecular mechanisms, the treatment of wild-type TP53 MCF-7 and mutant TP53 MDA-MB-231 human breast cancer cells with desferrioxamine (DFO), a model iron chelator, causes significant epigenetic alterations at the global and gene-specific levels. 23483119 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Immunohistochemical data suggest that p53 mutation is the commonest genetic alteration so far detected in primary breast cancer. 1694291 1990
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE The effects of the GST genotypes on the frequency and pattern of p53 mutations in 388 breast carcinomas were also studied. 11700265 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE TP53 mutations in primary breast carcinomas from white and African-Brazilian patients. 12792793 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Mutations of the p53 gene are the most frequent genetic lesions in breast cancer, suggesting a critical role for p53 protein in normal mammary cell growth control. 8674072 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Mutation in codon 72 of TP53 gene was not associated with breast cancer in Iranian patients. 17284368 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Herein, we analyze patterns of p53 mutations from Graz, Austria, another population with a high incidence of breast cancer. 7598762 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE The results of this study showed that the relationship of antioxidant vitamins with breast cancer does not differ according to the presence or absence of the p53 mutation. 12588696 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Previously, it was reported that mutations in p53 might render tumor cells more sensitive to Plk1 inhibition; however, p53 mutations are uncommon in breast cancer. 21953073 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE We conducted a case-control study to determine the prevalence of the R337H mutation by sequencing TP53 exon 10 in 123 women with breast cancer and 223 age- and sex-matched control subjects from southern Brazil. 19046423 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer. 17891171 2008