Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.400 | GeneticVariation | disease | BEFREE | However, combination of IL-1B C-allele (CT or CC) and IL-1RN *2-allele containing genotypes significantly decreased the risk of breast cancer (OR = 0.6, 95% CI = 0.39-0.99). | 16319982 | 2006 | ||||
|
0.400 | Biomarker | disease | BEFREE | Taken together, we have demonstrated a functional IL-1 system in breast cancer and observed an inverse correlation between IL-1alpha and sex steroid receptor expression. | 17010072 | 2006 | ||||
|
0.400 | Biomarker | disease | CTD_human | ERE-independent ERalpha target genes differentially expressed in human breast tumors. | 16298037 | 2005 | ||||
|
0.400 | Biomarker | disease | BEFREE | Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma. | 16464738 | 2005 | ||||
|
0.400 | AlteredExpression | disease | BEFREE | Our results suggest that: (a) the IL-1beta gene is a primary target of RA receptors in HMEC; (b) the enhanced expression of the IL-1beta gene does not mediate the RA-induced growth arrest of HMEC; and (c) the expression of the IL-1beta gene is low or absent in all three human breast carcinoma cell lines examined, but the defect in the IL-1beta signaling pathway may be different in ER positive versus ER negative carcinoma cells. | 12385002 | 2002 | ||||
|
0.400 | AlteredExpression | disease | BEFREE | In this study, we compared the mechanism(s) by which IL-1 beta induces collagenase gene expression in two very different cells, normal human foreskin fibroblasts (HFFs) and an aggressive breast cancer cell line, BC-8701 cells. | 9257189 | 1997 | ||||
|
0.400 | Biomarker | disease | BEFREE | The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. | 1832651 | 1991 |