Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 644192
Gene Symbol: NR2F2-AS1
NR2F2-AS1
0.010 Biomarker disease BEFREE Long non-coding RNA (lncRNA) NR2F2 antisense RNA 1 (NR2F2-AS1) is an oncogenic lncRNA in lung cancer. 31432342 2020
Entrez Id: 10306
Gene Symbol: CTPP
CTPP
0.010 Biomarker disease BEFREE A total of 388 patients who underwent CTPA and/or radionuclide ventilation perfusion scanning due to PE-suspected symptoms were stratified into LCPE (lung cancer and PE) group (n = 95), PE group (n = 99), LC group (n = 98) and control group (n = 96). 31747482 2020
Entrez Id: 2004
Gene Symbol: ELK3
ELK3
0.010 Biomarker disease BEFREE A recent study showed that increased plasma levels of the NET biomarker, citrullinated histone H3 (H3Cit), are associated with venous thromboembolism in pancreatic and lung cancer but not in other types of cancer, including breast cancer. 31048354 2020
Entrez Id: 100188949
Gene Symbol: LINC00426
LINC00426
0.010 AlteredExpression disease BEFREE Bioinformatics analysis of LINC00426 expression in lung cancer and its correlation with patients' prognosis. 31691516 2020
Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2
0.010 Biomarker disease BEFREE A recent study showed that increased plasma levels of the NET biomarker, citrullinated histone H3 (H3Cit), are associated with venous thromboembolism in pancreatic and lung cancer but not in other types of cancer, including breast cancer. 31048354 2020
Entrez Id: 693190
Gene Symbol: MIR605
MIR605
0.010 Biomarker disease BEFREE Besides this, miR-605-5p also promotes lung cancer cell carcinoma proliferation and metastasis in vivo. 31452243 2020
Entrez Id: 8535
Gene Symbol: CBX4
CBX4
0.010 Biomarker disease BEFREE However, the effect of CBX4 in the progression of lung cancer is not fully understood. 31724308 2020
Entrez Id: 79071
Gene Symbol: ELOVL6
ELOVL6
0.010 AlteredExpression disease BEFREE Correction: LCE: an open web portal to explore gene expression and clinical associations in lung cancer. 31501522 2020
Entrez Id: 26585
Gene Symbol: GREM1
GREM1
0.010 Biomarker disease BEFREE Autoantibodies against 5 TAAs (HMGB3, ZWINT, GREM1, NUSAP1 and MMP12) might have favorable diagnostic values in LC detection, and autoantibody against HMGB3 has the potential to serve as a serological biomarker in early-stage LC. 31629809 2020
Entrez Id: 6345
Gene Symbol: SRL
SRL
0.010 Biomarker disease BEFREE The optimum phenoxy-diketopiperazine-type Compound 6o exhibited high potent cytotoxicity (IC<sub>50</sub> = 4.0 nM) through SAR study of three series of derivatives, which was more potent than plinabulin (IC<sub>50</sub> = 26.2 nM) and similar to Compound 6b (IC<sub>50</sub> = 3.8 nM) against human lung cancer NCI-H460 cell line. 31759826 2020
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.010 Biomarker disease BEFREE Cellular prion protein transcriptionally regulated by NFIL3 enhances lung cancer cell lamellipodium formation and migration through JNK signaling. 31477838 2020
Entrez Id: 25821
Gene Symbol: MTO1
MTO1
0.010 Biomarker disease BEFREE In this review, we discuss the formation, classification, and biological functions of circRNAs, especially their molecular diagnostic values in common cancers, including gastric cancer (hsa_circ_002059, circ_LARP4, hsa_circ_0000190, hsa_circ_0000096, circ-SFMBT2, and circ_PVT1), hepatocellular carcinoma (circ_104075, circRNA_100338, circ_MTO1, and circZKSCAN1), colorectal cancer (hsa_circ_0136666 and hsa_circ_0000523), lung cancer (hsa_circ_0006427, circ_100876, and circ_ABCB10), breast cancer (hsa_circ_0089105, circAGFG1, and circEPSTI1), bladder cancer (circFNDC3B and circTFRC), and esophageal squamous cell carcinoma (circ_100876 and circ-DLG1). 31556152 2020
Entrez Id: 2444
Gene Symbol: FRK
FRK
0.010 Biomarker disease BEFREE Our study investigated the function of FRK in lung cancer. 31251822 2020
Entrez Id: 1757
Gene Symbol: SARDH
SARDH
0.010 Biomarker disease BEFREE The optimum phenoxy-diketopiperazine-type Compound 6o exhibited high potent cytotoxicity (IC<sub>50</sub> = 4.0 nM) through SAR study of three series of derivatives, which was more potent than plinabulin (IC<sub>50</sub> = 26.2 nM) and similar to Compound 6b (IC<sub>50</sub> = 3.8 nM) against human lung cancer NCI-H460 cell line. 31759826 2020
Entrez Id: 285313
Gene Symbol: IGSF10
IGSF10
0.010 AlteredExpression disease BEFREE In patients with lung cancer, IGSF10 expression was decreased, and the overall survival time of patients with lung cancer was significantly shortened. 31789390 2020
Entrez Id: 284340
Gene Symbol: CXCL17
CXCL17
0.010 AlteredExpression disease BEFREE Clinical tumor tissue samples, lung cancer cell lines and a TCGA dataset were used for CXCL17 expression analyses. 31832986 2020
Entrez Id: 55703
Gene Symbol: POLR3B
POLR3B
0.010 Biomarker disease BEFREE POLR3B has been implicated somatically in lung cancer but this germline finding is novel. is a significant eQTL in lung tissue. 31826912 2020
Entrez Id: 80263
Gene Symbol: TRIM45
TRIM45
0.010 AlteredExpression disease BEFREE High-level expression of TRIM45 in lung cancer tissue may promote cell apoptosis by activating p38 signal and inhibit proliferation by down-regulating p-ERK, which provides a new clue for understanding the tumorigenesis of lung cancer. 31663468 2020
Entrez Id: 100313781
Gene Symbol: MIR718
MIR718
0.010 Biomarker disease BEFREE MicroRNA‑718 serves a tumor‑suppressive role in non‑small cell lung cancer by directly targeting CCNB1. 31746372 2020
Entrez Id: 23326
Gene Symbol: USP22
USP22
0.010 AlteredExpression disease BEFREE Implications: This research provides new and exciting mechanistic insights into how USP22 overexpression promotes chemo-resistance in lung cancer. 31685642 2020
Entrez Id: 27319
Gene Symbol: BHLHE22
BHLHE22
0.010 AlteredExpression disease BEFREE Interestingly, the CA-4 resistant human lung carcinoma shows alteration of βI and βIII isotype levels, a higher expression of βI tubulin isotype and a decreased expression of βIII tubulin isotypes has been reported in drug resistant cell lines. 30831055 2020
Entrez Id: 23603
Gene Symbol: CORO1C
CORO1C
0.010 Biomarker disease BEFREE Coronin-3 (coronin-1C), a homotrimer F-actin-binding protein, has been reported to be important for metastasis in several types of cancers such as lung cancer, gastric cancer, and breast cancer. 31595425 2020
Entrez Id: 114044
Gene Symbol: MCM3AP-AS1
MCM3AP-AS1
0.010 Biomarker disease BEFREE On the basis of rescue assays, we identified that the overexpression of KPNA4 partly counteracted the suppressed effect of MCM3AP-AS1 knockdown on angiogenesis and progression in lung cancer cells. 31693222 2020
Entrez Id: 10112
Gene Symbol: KIF20A
KIF20A
0.010 Biomarker disease BEFREE Most importantly, further experiments demonstrated that decreased the expression of KLF20A significantly downregulated expression of p-JNK and MMP7, which indicated that knockdown of KIF20A alters lung cancer cell phenotype and regulates JNK pathways. 31557334 2020
Entrez Id: 55170
Gene Symbol: PRMT6
PRMT6
0.010 Biomarker disease BEFREE To interrogate the <i>in vivo</i> functions of PRMT6 in lung cancer, we developed a tamoxifen-inducible lung-targeted PRMT6 gain-of-function mouse model, which mimics PRMT6 amplification events in human lung tumors. 31619507 2020