Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Our findings suggested that CYP1A1 or GSTM1 variants may significantly modify the associations between level of serum trace metals (Cu, Zn, Se or Cr) and NSCLC, indicating the intriguing pathogenesis of lung cancer. 20638923 2011
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE While exploring non-linear interactions through CART analysis, smokers carrying the combination of EPHX1 113TC (Tyr/His), SULT1A1 213GG (Arg/Arg) or AA (His/His) and GSTM1 null genotypes showed the highest risk for lung cancer (OR = 3.73;95%CI = 1.33-10.55,p = 0.006), whereas combined effect of CYP1A1*2A 6235CC or TC, SULT1A1 213GG (Arg/Arg) and betel quid chewing showed maximum risk in non-smokers (OR = 2.93;95%CI = 1.15-7.51,p = 0.01). 22206016 2011
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Overall, CYP1A1 IleVal polymorphism is associated with lung cancer risk (GG vs. AG+AA: odds ratio=1.61, 95% confidence interval: 1.19-2.17; GG vs. AA: odds ratio=1.70, 95% confidence interval: 1.23-2.35). 22025136 2011
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE This may suggest that TP53 mutation and CDKN2A methylation specifically interact to promote lung tumorigenesis in subjects with CYP1A1 risk genotype but not in those with CYP1A1 wild-type homozygotes, implying different pathways for the development of lung carcinoma with respect to CYP1A1 polymorphism. 22154617 2011
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE This meta-analysis suggests that the MspI and exon 7 polymorphisms of CYP1A1 correlate with increased lung cancer susceptibility and there is an interaction between two genotypes of CYP1A1 polymorphism and smoking, but these associations vary in different ethnic populations, histological types of lung cancer and gender of case and control population. 22014025 2011
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE This meta-analysis demonstrated that the MspI and Ile-Val polymorphism of CYP1A1 is a risk factor associated with increased lung cancer susceptibility, but these associations vary in different ethnic populations. 21402622 2011
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE CYP1A1 haplotypes (in allele order CYP1A1*4, CYP1A1*2C, CYP1A1*2A) CGC and CGT were associated with an increased risk of lung cancer, whereas AAT was associated with decreased lung cancer risk in this population. 19608585 2010
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE 1.The CYP1A1 T6235C polymorphism (rs4646903) gene polymorphism has been linked to the development of coronary heart disease and cigarette smoking-related lung cancer. 19650794 2010
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE The polymorphism of CYP1A1*2A or CYP1A1*2B, and the linkage of CYP1A1*2A, CYP1A1*2B, GSTM1 and GSTT1 polymorphisms have been established as susceptible genes or gene-gene interactions of tobacco-related lung cancer. 20428802 2010
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Two CYP1A1 polymorphisms, m1 (T6235C transition) and m2 (A4889G transition), are associated with greater enzymatic activity and have been described as genetic susceptibility factors for lung cancer. 20054510 2010
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE The CYP1A1*2B allele (carrying MspI and Ile462Val mutations) was strongly associated with high lung cancer risk (OR = 4.59, CI:1.4-12.6, p <0.01). 20804547 2010
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Several polymorphisms within the CYP1A1 locus have been identified and have been shown to be associated with lung cancer risk, particularly in Asian populations. 19827888 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 AlteredExpression disease BEFREE Our data thus provides evidence of CYP1A1 expression in freshly isolated blood lymphocytes and differences in reactivity in individuals with variant genotypes of CYP1A1, suggesting that blood lymphocyte CYP1A1 expression profile could help in identifying individuals at risk to environment induced lung cancer. 19632247 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE To investigate haplotypes in the CYP1A1/2 region and lung cancer in African-Americans and Latinos, we conducted a case-control study (1998-2003). 19276377 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE The most significant risk for LC (OR = 3.2; 95% CI: 0.7-3.8) was found in the association of the homozygous variant of CYP1A1 gene at A2455G base change at Exon 7 (Val/Val) genotype. 19009239 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Moreover, the association between CYP1A1 rs2606345 genotype and lung cancer was significantly modified by intensity of cigarette smoking, suggesting an underlying dose-response mechanism. 19479063 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE The CYP1A1*2A gene cannot be linked with lung cancer risk in Brazilian patients at this time. 19750329 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer were examined in a northern Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI). 19963114 2009
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 Biomarker disease BEFREE Can CYP1A1 siRNA be an effective treatment for lung cancer? 18161011 2008
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Therefore, in 46 published studies in Chinese populations, we found evidence of an association between the CYP1A1 variant and GSTM1 null genotypes and increased risk of lung cancer. 17900751 2008
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE The lung cancer risk was increased several two-to fourfold in the patients carrying the genotype combinations of CYP1A1*2A and GSTM1 suggesting the role of gene-gene interaction in lung cancer. 18082227 2008
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 Biomarker disease BEFREE In our previous study, we reported that the combination of certain genotypes of GSTM1, GSTT1 and CYP1A1 is associated with lung cancer. 18415801 2008
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of lung adenocarcinoma in never-smoking Korean women, whereas specific combinations of variant genotypes for metabolic enzymes increase lung cancer risk considerably. 17980933 2008
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE DNA was obtained from blood samples and we studied by PCR-RFLP the distribution of CYP1A1 *2B (n=248) and *4 (n=222) polymorphisms in healthy controls and 222 lung cancer patients from a Mexican population. 18409147 2008
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
0.100 GeneticVariation disease BEFREE These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer risk in Asian populations. 18463401 2008