|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
|
SERPINA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>SERPINA1</i> gene and AAT protein play an active role in the pathogenesis of lung cancer and not just reflect inflammatory reaction related to cancer development.
|
31487965 |
2019 |
|
SERPINA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we believe that proteins like α2 macroglobulin, αmicroglobulin/bikunin, and SERPINA1 could be useful biomarkers for early detection of lung cancer and in monitoring its evolution.
|
31180588 |
2019 |
|
SERPINA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.
|
28368395 |
2017 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim is to know if AAT-deficient carriers have a higher risk of lung cancer in a study performed exclusively in never-smokers.
|
26287318 |
2015 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
|
22993338 |
2012 |
|
SERPINA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this case-control study was to investigate phenotypes and serum level of AAT in LC.
|
22331720 |
2012 |
|
SERPINA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer.
|
22507634 |
2012 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Non-MM variants of AAT and ELA2 genotypes with predicted intermediate or high activity could also represent a risk factor for aggressive form of lung cancer associated with extrathoracic metastases.
|
20521180 |
2011 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the association between alpha 1-antitrypsin deficiency (α₁ATD) carriers and lung cancer risk has been found, the effects of α₁ATD carriers and serum alpha 1-antitrypsin (α₁AT) concentration on non-small cell lung cancer (NSCLC) survival remained unclear.
|
21173712 |
2011 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP1A1 haplotypes (in allele order CYP1A1*4, CYP1A1*2C, CYP1A1*2A) CGC and CGT were associated with an increased risk of lung cancer, whereas AAT was associated with decreased lung cancer risk in this population.
|
19608585 |
2010 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to test the relationship between alpha1-AT deficient genotypes S and Z and lung cancer in Jordanian lung cancer patients.
|
16501672 |
2006 |
|
SERPINA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The lung represents an attractive target organ for somatic gene therapy strategy in that, (1) it is easily accessible by vectors, (2) most frequent hereditary disorders, cystic fibrosis (CF) and alpha1-antitrypsin deficiency (alpha1AT), occur in the lung, and (3) carcinoma of the lung is apparently a most common cause of death in humans.
|
11899243 |
2001 |
|
SERPINA1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interaction was examined between smoking and each of four factors previously found to be related to AO: alpha-1 antitrypsin (PiZ allele), ABO blood groups (A antigen), ABH non-secretor status, and first degree relationship to a COPD or lung cancer patient.
|
3485586 |
1986 |