Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Taken together, miR-10a targets PTEN to mediate the anti-tumor effect of icaritin in A549 cells, which provides a novel insight into the anti-tumor mechanism of icaritin and may provide a new strategy for lung cancer therapy. 31829310 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE These results suggested that SHCBP1 may be upregulated in lung cancer and it may serve a key role in the apoptosis of lung cancer cells; this effect was associated with the expression of PTEN. 31423258 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE And, it has been reported that both PTEN loss and NF-κB activation contribute to intrinsic EGFR-TKI resistance in EGFR-mutant lung cancer. 31497352 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE However, the molecular mechanism of EMT induced by PTEN inactivation is not clear in lung cancer. 30885348 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Down-regulation or inhibition of PRMT5 markedly reduced Akt phosphorylation at Thr308 and Ser473, whereas the expression of PTEN and mTOR phosphorylation was unchanged, indicating that PRMT5 was an important upstream regulator of Akt and induced lung cancer cell proliferation. 30461193 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear. 31266968 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE PTEN protein loss is a frequent event in lung cancer, but genetic alterations are not equally detected. 31404976 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy. 29378193 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE We suggested a tumor suppressor function of USP10 in lung cancer via deubiquitinating and stabilizing PTEN. 28852924 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Consistent with these findings, we observed increased PTEN phosphorylation and reduced nuclear PTEN levels in lung cancer patient samples establishing phosphorylation as a bona fide inactivation mechanism for PTEN in lung cancer. 29108454 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE We identified PTEN as miR-130b's major target and inversely correlated with miR-130b expression in LC. 29653464 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells. 29876362 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear. 29271375 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. 28662101 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE In contrast, engineered gain of USP18 expression in these same lung cancer cell lines stabilized PTEN protein. 27980214 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Recent evidence suggests that downregulation of gene of phosphatase and tensin homolog deleted on chromosome 10 plays an important role in acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in various types of cancers, including lung cancer. 28714370 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE These findings implicate the miR-23a/PTEN axis as a novel therapeutic target for lung cancer radiotherapy. 28852584 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE MicroRNA-101 suppresses progression of lung cancer through the PTEN/AKT signaling pathway by targeting DNA methyltransferase 3A. 28123563 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE The downregulation of miR21 and miR181b-1 and subsequent activation of PTEN/Akt and CYLD/IκB signaling axis leading to decreased NF-κB activity required to maintain the tumor-inhibiting effect of Rig-G.. Our findings contribute to a better understanding of the antitumor effect mechanism of Rig-G, as well as offer a novel strategy for lung cancer therapy. 27602766 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Decreased AKT phosphorylation (S473) was significantly associated with PTEN mutation under glucose starvation conditions in lung cancer cell lines. 26573869 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles. 27823967 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE We have developed a Drosophila lung cancer model by targeting Ras1(G12V)--alone or in combination with PTEN knockdown--to the Drosophila tracheal system. 26832408 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE The presence of PTEN expression may define a subset of patients with lung cancer appropriate for investigational therapeutic strategies. 27333149 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Our previous study observed that the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was downregulated in thrombin-stimulated lung cancer. 25861627 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE And then, we found there is a negative relationship between the expression of miR-205 and PTEN mRNA in lung cancer by analyzed. 25973003 2015