| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | Furthermore, HMGB1 in lung cancer cell supernatants promoted the formation of neutrophil extracellular traps (NETs), which was dependent on Toll-like receptor 4 (TLR4). | 31289487 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | Intraperitoneal administration of WT C57BL/6 mice with rhCNB resulted in a 50% reduction in LLC tumor growth, but failed to inhibit tumor growth in TLR4<sup>-/-</sup> littermates. | 31218844 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | The immunoenhancement effect of PSP against lung cancer is mediated by TLR4-MAPK/NF-κB signaling pathways. | 29343453 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer. | 28332554 | 2017 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Taken together, we conclude that expression of TLR4 in lung cancer is associated with PD-L1 and could predict the outcome of patients with NSCLC receiving pulmonary resection for cancer. | 28484456 | 2017 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Our further research indicates that Toll-like receptor 4 (TLR4)/molecules myeloid differentiation factor 88 (MyD88) signaling was up-regulated in MRSA-infected A549 cell. | 27545207 | 2016 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Determination of the Relationship Between rs4986790 and rs4986791 Variants of TLR4 Gene and Lung Cancer. | 26299699 | 2016 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | We found that both mRNA and protein levels of TLR4 and TLR9 were strongly expressed in lung cancer tissue. | 18763053 | 2009 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Therefore, we demonstrate that TLR4 expressed on human lung cancer cells is functionally active, and may play important roles in promoting immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. | 17328955 | 2007 |