Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE In vivo, the 4T1 mouse model of breast carcinoma was used to examine the efficacy of combinatorial therapy with docetaxel and anti-VEGFR3 on lymph node metastasis and tumor growth. 29976154 2018
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE VEGFR-3 expression was significantly associated with the presence of lymphovascular invasion (LVI) (P = 0.016) and lymph node metastases (pN+) (P = 0.028). 30446441 2018
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE In addition, higher MLVD was significantly associated with VEGFR-3 positive expression in tumors (<i>p</i><0.001), which facilitate lymph node metastasis and significantly worse survival rates. 30123080 2018
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE Multivariate logistic regression analysis revealed that T classification (P = 0.003), lymphatic invasion (P = 0.024), and Flt-4 expression in tumor cells (P = 0.046) were independently predictive of neck lymph node metastasis. 30416855 2018
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE The expression levels of STAT3, VEGF-C, and VEGFR-3 were significantly higher in the tumor tissues of patients with axillary lymph node metastasis than in those of patients without the metastasis. 29137038 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE There was a significant positive relationship between VEGF-D expression and lymph node metastasis (p < 0.05) however no significant association was found in VEGF-C and VEGFR-3 expressions. 28791841 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE Our meta-analysis found that VEGFR-3 expression was associated with depth of invasion and lymph node metastasis in gastric cancer. 28939099 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 PosttranslationalModification disease BEFREE Methylation of the VEGFR1 promoter (p = 0.003; 66/128 head and neck squamous cell carcinoma samples, 52%) and VEGFR3 promoter (p = 0.043; 53/128 head and neck squamous cell carcinoma samples, 41%) significantly correlated with recurrence, whereas methylation of the VEGFR2 promoter significantly correlated with lymph node metastasis (p = 0.046; 47/128 head and neck squamous cell carcinoma samples, 37%). 28718364 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue. 27666723 2016
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. 24379135 2014
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE HCC with high peritumoral co-expression of VEGF-C, VEGFR-1, and VEGFR-3 was associated with higher peritumoral distribution of macrophages (0.87%±0.26% versus 0.45%±0.20%), LNM (32.4% versus 12.0%), shorter TTR (10.2 months versus 34.5 months), and poor prognosis (19.4 months versus 49.3 months). 23737988 2013
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE A close correlation was found between VEGF-C/VEGFR-3 expression and lymph node metastasis in PLC, suggesting a role in metastasis of laryngeal carcinomas. 22502683 2012
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE Immunohistochemistry for lymphatic vessel endothelial receptor 1 (LYVE-1), Ki-67, Twist, vascular endothelial growth factor C (VEGF-C), and vascular endothelial growth factor receptor 3 (VEGFR-3) was performed to detect lymphatic vessel density (LVD), cell proliferation levels and the expressions of Twist, VEGF-C, and VEGFR-3 were determined from 66 primary supraglottic carcinoma tissue samples from 36 patients with lymph node metastasis (pathological N+, pN+) and 30 patients without metastasis (pathological N0, pN0). 21740802 2011
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE VEGF-C and VEGF-D expressions were associated with VEGFR-3 expression and were significantly correlated with both peritumoral lymphangiogenesis and lymph node metastasis. 18561194 2008
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE The expression of VEGF-C and lymphatic endothelial marker VEGFR-3 was significantly greater in patients with lymph node metastasis than in those without metastasis, but no different expression level of VEGF-D and LYVE-1 was detected in both groups of patients. 17174733 2007
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE VEGF-C, VEGF-D, and VEGFR-3 were analyzed in 91 R(0)-resected primary gastric adenocarcinomas, corresponding noncancerous gastric mucosa, and lymph node metastases employing immunohistochemistry and/or in situ hybridization. 16344322 2006
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE We failed to find a positive association between VEGF-C and VEGFR-3 mRNA expression and lymph node metastasis in NSCLC. 16755294 2006
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE In addition, sVEGFR3-Fc serum levels required for efficient blockade of lymph node metastases are strictly dependent on the VEGF-C levels generated by the primary tumor. 16061674 2005
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE Expression of vascular endothelial growth factor C (VEGF-C) and VEGF receptor-3 in human prostate cancer is associated with regional lymph node metastasis. 15880525 2005
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic cancer, we analyzed the expression pattern of the vascular endothelial growth factor-D (VEGF-D), its receptor VEGF-receptor-3 (VEGFR-3) and the lymphatic endothelium-specific hyaluronan receptor LYVE-1 in a panel of 19 primary human ductal pancreatic tumors and 10 normal pancreas specimens. 16077915 2005
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE In addition, the role of blood vascular vessel, lymph vessel, and Flt-4-positive vessel densities were studied in relation to their suspected association with lymph node metastasis, and with VEGF-D expression. 15803188 2005
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 AlteredExpression disease BEFREE We have then utilized RNase protection and ELISA to measure the relative levels of VEGF B, C, D and flt-1, KDR, flt-4 and flt-4t(Delta773-1081) expression in freshly isolated benign prostatic hyperplasia or BPH tissue (n=21), primary prostate cancers (n=82) and matching sentinel lymph node metastases from stage T2a-T2b/T3 tumors (n=52). 15107801 2004
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE This study was undertaken to determine whether vascular endothelial growth factor-C (VEGF-C) and the expression of its receptor VEGF receptor-3 (VEGFR-3) are correlated with lymph node metastasis in human colorectal cancer and whether their expression levels might be used to predict lymph node metastasis. 12660643 2003
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE Tumor lymphangiogenesis and lymph node metastasis were studied immunohistochemically using antibodies against lymphatic vessel hyaluronan receptor -1 (LYVE-1), VEGF receptor-3 (VEGFR-3), PECAM-1, pan-cytokeratin and estrogen dependent pS2 protein. 11948478 2002
Entrez Id: 2324
Gene Symbol: FLT4
FLT4
0.100 Biomarker disease BEFREE The short form of the alternatively spliced flt-4 but not its ligand vascular endothelial growth factor C is related to lymph node metastasis in human breast cancers. 11106244 2000