Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE Prediction of lateral neck lymph node metastasis according to preoperative calcitonin level and tumor size for medullary thyroid carcinoma. 31483088 2019
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 Biomarker disease BEFREE At univariate analysis, the cure was achieved more frequently in more recently operated patients (64.5% vs 38.6%; p = 0.0012), in disease staging I/II (86.5% vs 13.5%; p < 0.0001), in patients undergoing preoperative calcitonin screening (63.8% vs 23.5%; p < 0.0001) and in the absence of lymph node metastases (86.5% vs 13.5%; p < 0.0001). 30903267 2019
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE Postoperative RET gene test and pathological analysis were performed with the surgical specimens; serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) levels were tested pre- and postoperatively, to evaluate the association between RET mutations and cervical lymph node metastasis in MTC. 31494787 2019
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 GeneticVariation disease BEFREE Formalin-fixed, paraffin-embedded primary thyroid tumors and lymph node metastases from MTC patients were evaluated for calcitonin, RB, and phosphorylated RB (pRB) expression by immunohistochemistry. 29105562 2017
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE In patients with established primary tumors, systematic surgical removal of lymph node basins (compartmental dissection) should be guided by ultrasound mapping of lymph node metastases and level of serum calcitonin. 26539937 2016
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE At primary surgery, all patients (n = 13) with lymph node metastases had preoperative basal calcitonin levels ≥68 pg/mL, and all patients (n = 17) without central lymph node dissection and preoperative basal calcitonin <40 pg/mL were biochemically cured. 27400880 2016
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE At enrollment, high miR-21 levels were associated with high calcitonin levels (P = .0003), lymph node metastases (P = .001), and advanced stages (P = .0003). 25316501 2015
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 Biomarker disease BEFREE Serum calcitonin, (R(2) = 0.032; P = 0.017), tumor volume (P = 0.0079), lymph node metastasis (P = 0.033), and staging (P = 0.0652) were negatively correlated with the hCaKIINα mRNA expression. 24449826 2014
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE Patients with thyroid tumor >5 mm detected by ultrasound, and basal calcitonin levels >40 pg/ml, frequently have cervical and upper mediastinal lymph node metastasis. 22584721 2012
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE Significantly associated determinants of outcome in univariate analysis were higher age at surgery, no age-appropriate prophylactic surgery according to risk level, elevated preoperative calcitonin levels, affected codon, and the presence of lymph node metastases at surgery. 20063095 2010
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE There was a significant relationship between the presence of lymph node metastases and increased pretherapeutic basal calcitonin levels. 19638924 2009
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE Nine of 16 patients had MTC (mean age 44.7 years, range 29-59 years) and elevated basal calcitonin levels; 6 of these 9 had lymph node metastases. 19472011 2009
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE All patients with lymph node metastases had elevated basal calcitonin levels. 15517481 2004
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE However, all patients with lymph node metastases (LNMs) had elevated calcitonin levels. 15517488 2004
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 AlteredExpression disease BEFREE Among patients with lymph node involvement, undetectable calcitonin level was obtained in 57% of patients with less than or with 10 lymph node metastases and in 4% of patients with more than 10 (P < 0.01). 12727956 2003
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 Biomarker disease BEFREE The two groups did not differ in terms of multifocality of MTC (pT1b), lymph node involvement (pN1) or bilateral lymph node metastasis (pN1b), or preoperative stimulated and postoperative basal and stimulated serum calcitonin. 11376404 2001
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.100 GeneticVariation disease BEFREE Bilateral lymph node dissection should be performed if LNMs are suspected or when patients with elevated calcitonin are older than 15 years. 9606292 1998