Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 GeneticVariation disease BEFREE Colonized patients contribute to transmission, but CDI cases are more likely linked to other infected patients than colonized patients in this cohort with high rates of the NAP1/027/ST1 strain, highlighting the importance of local prevalence of virulent strains in determining transmission dynamics. 29846557 2019
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE Whole genome sequencing of CA-CDI isolates confirmed that NAP 1-like pulsotypes are commonplace in CA-CDI. 30170546 2018
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078. 30052178 2018
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 GeneticVariation disease BEFREE The increased incidence and severity of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain. 29174729 2018
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE Recent outbreaks of CDI have been associated with the emergence of hypervirulent strains, such as NAP1/BI/027, many strains of which also produce a third toxin, binary toxin (CDTa and CDTb). 28125650 2017
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE An outbreak of Clostridium difficile infection (CDI) caused by ribotype 027 (B1/NAP1) began in our hospital in November 2014, and produced 141 episodes in the following months. 28501926 2017
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE The NAP1 strain did not increase disease severity, mortality, or recurrence in this study, although the incidence of NAP1-positive healthcare associated-CDI was low. 28645479 2017
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE The BI/NAP1/027 strain caused CDI in only 1 patient. 25782900 2015
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 GeneticVariation disease BEFREE Over 75 % of CDIs with NAP1 was hospital-acquired, and more often proceeded with generalized infection (p < 0.05). 24213847 2014
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE The gold standard was the toxigenic culture for the diagnosis of CDI and PCR ribotyping for the identification of the NAP1/027/BI strain. 21487764 2011
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) has been increasing in incidence and severity in recent years, coincident with the spread of a "hypervirulent" strain, REA type BI (ribotype 027, PFGE NAP 1). 19755166 2009
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE Infection with the epidemic NAP-1 strain was not associated with metronidazole failure in endemic CDI. 19081526 2008
Entrez Id: 10787
Gene Symbol: NCKAP1
NCKAP1
0.100 Biomarker disease BEFREE We compared multilocus variable-number tandem-repeat analysis (MLVA) and macrorestriction endonuclease analysis using pulsed-field gel electrophoresis (PFGE) to determine their utility to identify clusters of Clostridium difficile infection (CDI) among 91 isolates of PCR ribotype 027 (NAP1, for North American pulsed-field type 1) from nine hospitals (and 10 general practitioners associated with one institution) in England. 18216211 2008