Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Combined application of PLR, HPR, and CEA may improve the diagnostic efficacy of distinguishing between colon cancer and benign colon tumors. 31809747 2020
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE Recently, a large-scale study on colon cancer revealed that "preoperatively elevated and postoperatively normalized CEA levels" is not an indicator of poor prognosis. 31799750 2020
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Enhancement of chemosensitivity in 5-fluorouracil-resistant colon cancer cells with carcinoembryonic antigen-specific RNA aptamer. 31028570 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE A multivariate analysis showed that age (odds ratio [OR] 0.97, P < 0.001), tumor size (OR 1.01, P < 0.001), moderate (OR 1.77, P = 0.001) or poorly differentiated/undifferentiated tumor (OR 5.60, P < 0.001), right colon cancer (OR 1.39, P = 0.008), and a positive carcinoembryonic antigen level (OR 1.51, P = 0.004) were independent predictive factors for LNM. 31021492 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE CEA level and Poorly differentiated histology of colon cancer was significantly correlated with high NLR (P = 0.005 and P = 0.048, respectively). 30941323 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth. 31192764 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Furthermore, serum levels of GSN were significantly lower in colon cancer patients than those in healthy volunteers, and ROC curves showed serum level of GSN had a better diagnostic value for colon cancer (AUC=0.932) than the traditional tumor biomarker Carcinoembryonic Antigen (CEA) or Carbohydrate Antigen 19-9 (CA199). 30854138 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Using a transgenic mouse model constitutively expressing human CEA in a spatiotemporal manner as a self-protein and a syngeneic mouse colon cancer cell line, MC38-CEA, overexpressing CEA, we tested the potential of a novel genetic immunotherapy approach against CEA-expressing tumors, using recombinant adeno-associated virus vector encoding CEA (rAAV-CEA) and appropriately timed immune adjuvant application. 30666318 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Secondly, ENST00000455974 showed a better sensitivity and specificity than CEA and CA19-9 in the diagnosis of pMMR CC by drawing the receiver operating characteristic (ROC) curve. 30473216 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE This large population-based and propensity score-matched study with long follow-up time provides the first evidence that stage T1N0M0 colon cancer with the elevation of preoperative serum CEA would be a surrogate of aggressive tumor biology and predict poor prognosis. 31016378 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Carcinoembryonic antigen (CEA), a routinely used marker for colon cancer, was used as a test glycoprotein. 31581071 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Clinical value of a diagnostic score for colon cancer based on serum CEA, CA19-9, cytokeratin-1 and mucin-1. 29734875 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE To investigate whether patients with elevated preoperative CEA that normalizes after colon cancer resection have a higher risk of recurrence than patients with normal preoperative CEA. 29270608 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE ChIP-sequencing revealed that Lv1 overexpression in IRF1-treated cells induces transcriptional silencing across many genes, including <i>DCC</i> (<u>d</u>eleted in <u>c</u>olorectal <u>c</u>arcinoma), associated with CEACAM5 in colon cancer. 29720400 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE Analysis of CXCL17 messenger RNA is particularly useful to detect less differentiated colon cancer tumors expressing relatively low carcinoembryonic antigen messenger RNA levels. 30198422 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Combined TC, HDL, CEA and CA19-9 as a diagnostic marker for colon cancer had the highest positive predictive rate in comparison with individual, two or three of the parameters. 30458796 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Biomarkers such as carcinoembryonic antigen (CEA) show low sensitivity (~ 40%), and thus the demand for novel biomarkers for CC diagnosis is increasing. 30382917 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE The prognostic factors of SAR were age (stage II CC and stage III RC), female gender (stage III RC), high CEA level (stage II RC), histological type (stage III CRC), nodal status (stage III CC), recurrence within 1 year (stage III RC), M1b recurrence (stage II CRC), local recurrence (stage II CC), and no surgical resection after recurrence (stage II and III CRC). 29876002 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE Positive carcinoembryonic antigen (CEA) messenger RNA (mRNA) in peritoneal lavage is associated with poor prognosis in patients with colon cancer. 28291565 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE The aim of this study was to analyze changes in the autonomic activity of colon cancer patients using heart rate variability (HRV) and blood pressure variability (BPV) measures, and to verify if HRV and BPV parameters correlate with hemodynamic indices in this group and the plasma levels of CEA. 29953262 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Moreover, both piRNAs exhibited satisfactory diagnostic performance also in patients with stage I disease and enabled detection of colon cancer with higher sensitivity than currently used biomarkers CEA and CA19-9. 29976566 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE The ROC curve analysis showed that serum TRIM72 has a superior diagnostic value (the area under the curve (AUC) = 0.829) than the traditional tumor biomarkers, carcinoembryonic antigen (CEA) (AUC = 0.707) and carbohydrate antigen 19-9 (CA199) (AUC = 0.750), and the combination of TRIM72 with CEA and CA199 showed the best diagnostic value for colon cancer (AUC = 0.928). 29806630 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE Using the National Cancer Database (2004-2014), we identified 45,449 individuals with stage I and II colon cancer who did not receive adjuvant chemotherapy and had preoperative CEA levels available. 29502035 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Carcinoembryonic antigen (CEA) is a tumor marker for detecting recurrences of adenocarcinomas such as colon cancer. 29997989 2018
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE The high expression of Nav1.5 in colon cancer tissues was associated with high preoperative carcinoembryonic antigen level [odds ratio (OR) = 2.980; 95% confidential interval (CI) 1.163-7.632; P = 0.023] and high ER-β expression (OR = 2.808; 95% CI 1.243-6.343; P = 0.013). 29122010 2017