Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE The ectopic expression of mimic miR-31 showed significant 5-FU resistance in the parental DLD-1 cells, while anti-miR-31 caused significant growth inhibition in DLD/F cells; that is, 5-FU-resistant colon cancer cell line DLD-1 under exposure to 5-FU. 31162779 2019
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines. 31520321 2019
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE The IC<sub>50</sub> values varied from 0.36 μM (against MCF7 cells) to 5.65 μM (towards colon carcinoma DLD-1 cells) for 9, from 9.78 μM (against MCF7 cells) to 67.68 μM (against HepG2 cells) for 13 and 0.18 μM (towards HepG2 cells) to 72 μM (towards Caco-2 cells) for the reference drug, doxorubicin. 29378558 2018
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 GeneticVariation disease BEFREE We examined the anti-proliferative effect of miR-143#12 and the mechanism in human colon cancer DLD-1 cell (G13D) and other cell types harboring K-Ras mutations. 29498789 2018
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE We knocked down fascin1 expression with shRNA retrovirally transduced into a DLD-1 colon cancer and L929 fibroblast-like cell lines and used luciferase reporter assays and co-immunoprecipitation to identify fascin1 targets. 29496994 2018
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability. 29496963 2018
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE We validated Gn binding to MSI1 using surface plasmon resonance, nuclear magnetic resonance, and cellular thermal shift assay, and tested the effects of Gn on colon cancer cells and colon cancer DLD-1 xenografts in nude mice. 30097032 2018
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE The effects of fucoidan from the brown alga <i>Fucus evanescence</i> on the activity of alpha-NaGalase in human colon carcinoma DLD-1 cells and on the biosynthesis of this enzyme were investigated. 29748462 2018
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Furthermore, this method could detect multiple TFs in human colon cancer DLD-1 cells and reflect the variation in their cellular levels after stimulation. 28657304 2017
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Gated MSNs are nontoxic to colon cancer DLD-1 cells, and ATTO 430LS dye delivered correlated with the amount of Le<sup>x</sup> antigen overexpressed at the DLD-1 cell surface. 29210428 2017
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE First, we compared the effect of DM-celecoxib with that of celecoxib on the human colon cancer cell lines HCT-116 and DLD-1. 27761963 2017
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE DLD-1 and SW480 colon cancer cell lines were transfected with vectors expressing transgenes or small hairpin RNAs and incubated with recombinant PGE<sub>2</sub>, with or without pharmacologic inhibitors of signaling proteins, and analyzed by immunoblot, immunofluorescence, quantitative reverse-transcription polymerase chain reaction, transcriptional reporter, and proliferation assays. 27864128 2017
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Literatures support potent anticancer activity of napthoquinone derivatives in human colon cancer, present study evaluates the effect and mechanism of LS on chemical induced colon cancerous rats and human colon cancer DLD-1 cells, the study was supported by endoscopy, histological and immunohistochemistry analysis. 28222396 2017
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Synthesis, structural characterization and biological activity of novel Knoevenagel condensates on DLD-1 human colon carcinoma. 28438541 2017
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Global shotgun proteomic analysis of isogenic DLD-1 and RKO colon cancer cell lines expressing mutant and wild type KRAS or BRAF, respectively, failed to identify significant differences (at least 2-fold) in metabolic protein abundance. 27340238 2016
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 GeneticVariation disease BEFREE To discover the small molecule inhibitors of the Wnt/β-catenin pathway, we conducted high-throughput screening in APC-mutant colon cancer DLD-1 cells using a transcriptional reporter assay, which identified a selective Wnt/β-catenin pathway inhibitor, K-756. 27196752 2016
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigated the dynamic relationship between the 78-kDa glucose-regulatory protein (GRP78) and the phosphoinositide 3-kinase (PI3K)/Akt pathway. 26225471 2015
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE In the current study, we established a TRAIL-resistant human colon cancer DLD-1 cell line to clarify the mechanisms of TRAIL-resistance and developed agents to cancel its machinery. 26304927 2015
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Combination treatment of human colon cancer DLD-1 cells with 2 of these compounds, each at its IC20 concentration, induced apoptosis by stimulating both intrinsic and extrinsic apoptosis signaling pathways. 24854570 2015
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE In the present study, we examined the effect of differentiation-inducing factor-3 (DIF-3), a monochlorinated metabolite of DIF-1 that is also produced by D. discoideum, on human colon cancer cell lines HCT-116 and DLD-1. 25913757 2015
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Earlier we established Fluorouracil (5-FU)-resistant human colon cancer DLD-1 cells (DLD-1/5FU) from parental 5-FU- sensitive DLD-1 cells. 24447928 2014
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 GeneticVariation disease BEFREE Effects of parafibromin expression on the phenotypes and relevant mechanisms in the DLD-1 colon carcinoma cell line. 23991985 2013
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE Taken together, culturing DLD-1 cells in serum-free medium enriches CSCs and the expression of KLF4 is essential for the characteristics of CSCs in DLD-1; thus KLF4 can be a potential therapeutic target for treating colon cancer. 23418515 2013
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE We used SW480 and DLD-1 human colon carcinoma cells, expressing estrogen receptor-β (ER) in subsequent in vitro studies. 22396198 2012
Entrez Id: 1738
Gene Symbol: DLD
DLD
0.100 Biomarker disease BEFREE In vitro analyses showed that ectopic expression of miR-215 decreases viability and migration, increases apoptosis and promotes cell cycle arrest in DLD-1 and HCT-116 colon cancer cell lines. 22469014 2012